Isolation and Structural Identification of a Tetraene Macrolide Produced by Streptomyces hygrospinosus var. Beijingensis
YAO Fen1，KANG Qianjin1，LIN Shuangjun1，ZHU Changxiong2， YOU Delin1，DENG Zixin1
(1.School of Life Sciences and Biotechnology, Shanghai Jiaotong University, Shanghai 200240, China； 2.Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing 100081, China)
Abstract A tetraene compound was purified from the secondary metabolites of Streptomyces hygrospinosus var. Beijingensis, the producing strain of Agroantibiotic 120. The results of LCMS on molecular weight and NMR on structural identification show that it is Tetramycin B with the UV absorption spectrum of tetraene macrolide antibiotics. The bioassay result shows it inhibits the growth of Saccharomyces cerevisiae, indicating it is one of the effective components in Agroantibiotic 120.
Received: 06 April 2010
Published: 27 January 2011
