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| Experimental Study of Transfersomes in Hypertrophic Scar Penetration in Vitro |
| ZHANG Zhen-1, WO Yan-1, ZHANG Yi-Xin-1, MAO Xiao-Hui-2, QIAN Yun-Liang-1, WANG Dan-Ru-1, HE Rong-3, CUI Da-Xiang-3 |
| (1.Department of Plastic and Reconstructive Surgery, the Ninth Peoples Hospital, Shanghai 200021, China; 2. Department of Otorhinolaryngology Head and Neck Surgery, the Third People's Hospital, Affiliated to Shanghai Jiaotong University Shanghai 201900, China; 3. Institute of Micro-Nano Science and Technology, Shanghai Jiaotong University, Shanghai 200240, China) |
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Abstract Hypertrophic scar has its special tissue structures. Drug penetration in the local is the key role of topical effect. The purpose of this study is to characterize a novel transdermal delivery carrier: transfersomes containing 5fluorouracil (5-FU) to investigate the delivery of drugs from transfersomes in human hypertrophic scar in vitro. Cumulative 5FU that permeated hypertrophic scar and skin after 24 h is: transfersomes via hypertrophic scar (T-Scar) > 5-FU solution via hypertrophic scar (CScar) > transfersomes via skin (T-Skin) > 5-FU solution via skin (C-Skin). The depositions of 5FU and intensities of fluorescence after application for 24 hours are: T-scar> T-skin> C-scar> C-skin. Conclusively, the delivery ability of transfersomes is most efficient in human hypertrophic scar. The test results indicate that transfersome is a high efficient carrier in hypertrophic scar.
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Received: 05 July 2010
Published: 29 June 2011
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