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| Relationship Between Dyslipidemia and Proteinuria in Patients with Diabetic Nephropathy |
| LI Junhui,CHENG Dongsheng,WANG Feng,FEI Yang,XUE Qin,WANG Niansong
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| (School of Medicine, Soochow University, Suzhou 215006, Jiangsu, China; Department of
Nephrology, Sixth People’s Hospital Affliated to Shanghai Jiaotong University， Shanghai 200233, China) |
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Abstract Abstract： The relationship between 24 h urine protein excretion with dyslipidemia in diabetic nephropathy(DN) patients was evaluated. A total of 122 DN patients (49 females and 73 males) with an average age of (62.26±12.67) were included in this study. 24hour urine were collected for 24h protein(24 h pro) measurement and blood samples were taken as lipid parammeters. According to 24 h pro assays, subjects were divided into nephrotic group and nonnephrotic group. Lipid profiles and correlation analysis were compared between the two groups. It is found that the levels of total cholesterol(TC), non high density lipoprotein (NHDL), lipoprotein (a) ［Lp(a)］, and apolipoprotein B (ApoB) were much higher in nephrotic group compared with nonnephrotic one (P<0.05). In correlation analysis, TC, NHDL, ApoB and ApoE were found to be related to 24 h urine protein and HbA1C (P<0.01) respectively and Lpa was related to 24 h pro and eGFR. LDLC and TG were independently associated with HbA1C (P<0.01) while ApoA1 was only associated with 24 h pro (P<0.05). In each group classified according to quartiles of lipid profile, it is found that the proportion of patients with >3.5 g/24 h urine protein excretion grew progressively with the increase in TC, NHDLC, TG, ApoA1, ApoB,Lpa and ApoE (P<0.05) while LDLC and HDLC had no statistical differences (P>0.05). Conclusion: In patients with diabetic nephropathy, an obvious dyslipidemia was observed with increase of 24 h urine protein excretion, especially in those with nephrotic syndrome who mainly present with the an elevation in TC, NHDL, Lpa and ApoB. Since dyslipidemia could aggravate the progress of kidney disease, an effective control of lipid profile is likely to improve the prognosis.
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Received: 15 April 2015
Published: 28 March 2016
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