Comparison of Osteogenesis Between Two Kinds of Stem Cells from Goat</br>
Combined Calcium Phosphate Cement in Tissue Engineering

doi:10.1007/s12204-011-1200-x

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Abstract Abstract: To explore the possible mechanism of osteogenesis for deciduous
teeth stem cells (DTSCs) in vivo/ vitro, stem cells from goat deciduous
teeth (SGDs) were firstly isolated, induced and transplanted into
immunocompromised mice. The SGDs's mineralization pattern and osteogenesis
were compared with bone marrow messenchymal stem cells (BMMSCs) from goats.
SGDs have similar osteogenic differentiation pattern in vitro and bone-like
tissue formation mechanism in vivo to BMMSCs; moreover SGDs have stronger
alkaline phosphatase (ALP) gene expression and osteopontin (OPN)
gene expression levels than BMMSCs; also SGDs can form more bone-like
tissues than BMMSCs when cell-scaffold compounds are transplanted into
immunocompromised mice. This pre-clinical study in a large-animal model
confirms that DTSCs may be an appropriate source of stem cells in repairing
bone defects with tissue engineering.

Received: 12 August 2011 Published: 29 October 2011

PACS:

R 782.1

Fund:

the Science and Technology Commission Fund of Shanghai Municipality (No.09JC1411700), the Collaboration Projects of Development and Research from Basic Science of Stomatology of Shanghai (No. S30206-KF09), and the Fund of Shanghai Jiaotong University School of Medicine (No. 09XJ21030)

Corresponding Authors: ZOU De-rong (邹德荣) E-mail: derongzou@gmail.com

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http://www.qk.sjtu.edu.cn/jsjtune/EN/10.1007/s12204-011-1200-x OR http://www.qk.sjtu.edu.cn/jsjtune/EN/Y2011/V16/I5/628