The upper end responses of a steel catenary riser (SCR) were predicted using the hull/riser/mooring full coupled model, which was then applied to the global finite element analysis of the SCR, where the SCR-soil interaction was simulated by the developed touchdown zone (TDZ) element. The TDZ element could capture the mobilization and release of the clay suction, and account for the seabed trench shape. By changing the seabed characteristic parameters, the parametric studies were conducted, and the fatigue sensitivity of the SCR near touchdown point (TDP) to the seabed parameters was obtained by using the rain flow counting methodology.