收稿日期: 2025-07-04
修回日期: 2025-10-30
网络出版日期: 2025-12-25
基金资助
国家自然科学基金项目(82473013);上海市科委项目(18411953100);上海市科委项目(20DZ2201900);上海市科委项目(25DZ2200200);教育部-上海市生物医药临床研究与转化协同创新中心项目(CCTS-2022202);教育部-上海市生物医药临床研究与转化协同创新中心项目(CCTS-202302);中国博士后科学基金(2025M782160)
Application of artificial intelligence in medical image data processing for digestive tract tumors
Received date: 2025-07-04
Revised date: 2025-10-30
Online published: 2025-12-25
近年来,随着人工智能(artificial intelligence, AI)算法模型的快速发展,出现了以图像分类为主要功能的卷积神经网络(convolutional neural network, CNN)算法、决策分类的决策树和支持向量机模型、提高模型识别精准性的注意力机制模型、完成图像中病灶识别定位的目标检测模型,以及实现图像中病灶精准分割的语义分割和实例分割模型等。AI的CNN与医学影像深度融合,显著提高了疾病诊断的效率和精准率。随着数字医学水平提高,AI在疾病诊疗路径中图像数据结合点进一步拓宽。除了传统的放射学、超声学、内镜学和病理学等图像,手术切除标本图像和类器官图像等非经典图像也逐步被纳入了AI研究范畴。AI的深度介入有助于解码多维数据中的隐性信息,不断改变疾病的诊治模式。可以预见,未来AI算法与各类疾病诊疗设备镶嵌整合,将成为疾病诊断、治疗乃至发展趋势预判的有力工具。
杨蕊馨 , 于颖彦 . 人工智能在消化道肿瘤医学图像数据处理的应用[J]. 诊断学理论与实践, 2025 , 24(06) : 605 -612 . DOI: 10.16150/j.1671-2870.2025.06.005
In recent years, with the rapid development of artificial intelligence (AI) algorithm models, a variety of approaches have emerged, such as convolutional neural networks (CNN) algorithms mainly for image classification, decision trees and support vector machine models for decision classification, attention mechanism models for impro-ving identification accuracy, object detection models for lesion identification and localization in images, and semantic segmentation and instance segmentation models for precise lesion segmentation in images. The deep integration of AI-based CNN with medical imaging has significantly improved the efficiency and accuracy of disease diagnosis. With the improvement of digital medicine, the integration points of image data with AI in disease diagnosis and treatment pathways have further expanded. Besides traditional images, (radiology, ultrasonography, endoscopy, pathology), non-classical images, such as surgical resection specimen images and organoid images, are gradually incorporated into the scope of AI research. The deep involvement of AI helps decode hidden information in multi-dimensional data, conti-nuously transforming disease diagnosis and treatment patterns. In the foreseeable future, the integration of AI algorithms with various disease diagnosis and treatment devices will become powerful tools for disease diagnosis, treatment, and even prediction of development trends.
| [1] | PESAPANE F, CODARI M, SARDANELLI F. Artificial intelligence in medical imaging: threat or opportunity? Radiologists again at the forefront of innovation in medicine[J]. Eur Radiol Exp, 2018, 2(1):35. |
| [2] | HIRASAWA T, AOYAMA K, TANIMOTO T, et al. Application of artificial intelligence using a convolutional neural network for detecting gastric cancer in endoscopic images[J]. Gastric Cancer, 2018, 21(4):653-660. |
| [3] | YANG R, YU Y. Artificial convolutional neural network in object detection and semantic segmentation for medical imaging analysis[J]. Front Oncol, 2021, 11:638182. |
| [4] | SHUKLA P, VERMA A, ABHISHEK, et al. Interpreting SVM for medical images using Quadtree[J]. Multimed Tools Appl, 2020, 79(39-40):29353-29373. |
| [5] | NGUYEN THI CAM H, SARLAN A, ARSHAD N I. A hybrid model integrating recurrent neural networks and the semi-supervised support vector machine for identification of early student dropout risk[J]. Peer J Comput Sci, 2024, 10:e2572. |
| [6] | SCHLEMPER J, OKTAY O, SCHAAP M, et al. Attention gated networks: Learning to leverage salient regions in medical images[J]. Med Image Anal, 2019, 53:197-207. |
| [7] | ZHOU Q, ZHOU Y, HOU N, et al. DFA-UNet: dual-stream feature-fusion attention U-Net for lymph node segmentation in lung cancer diagnosis[J]. Front Neurosci, 2024, 18:1448294. |
| [8] | LI H, NAN Y, DEL SER J, et al. Large-kernel attention for 3D medical image segmentation[J]. Cognit Comput, 2024, 16(4):2063-2077. |
| [9] | VENHUIZEN F G, VAN GINNEKEN B, LIEFERS B, et al. Deep learning approach for the detection and quantification of intraretinal cystoid fluid in multivendor optical coherence tomography[J]. Biomed Opt Express, 2018, 9(4):1545-1569. |
| [10] | HE W, LI C, NIE X, et al. Recognition and detection of aero-engine blade damage based on Improved Cascade Mask R-CNN[J]. Appl Opt, 2021, 60(17):5124-5133. |
| [11] | TIAN Z, ZHANG B, CHEN H, et al. Instance and panoptic segmentation using conditional convolutions[J]. IEEE Trans Pattern Anal Mach Intell, 2023, 45(1):669-680. |
| [12] | MA X B, XU Q L, LI N, et al. A decision tree model to distinguish between benign and malignant pulmonary nodules on CT scans[J]. Eur Rev Med Pharmacol Sci, 2023, 27(12):5692-5699. |
| [13] | LUO H, XU G, LI C, et al. Real-time artificial intelligence for detection of upper gastrointestinal cancer by endoscopy: a multicentre, case-control, diagnostic study[J]. Lancet Oncol, 2019, 20(12):1645-1654. |
| [14] | AN P, YANG D, WANG J, et al. A deep learning method for delineating early gastric cancer resection margin under chromoendoscopy and white light endoscopy[J]. Gastric Cancer, 2020, 23(5):884-892. |
| [15] | WICKSTR?M K, KAMPFFMEYER M, JENSSEN R. Uncertainty and interpretability in convolutional neural networks for semantic segmentation of colorectal polyps[J]. Med Image Anal, 2020, 60:101619. |
| [16] | YANG R, ZHANG J, ZHAN F, et al. Artificial intelligence efficiently predicts gastric lesions, Helicobacter pylori infection and lymph node metastasis upon endoscopic images[J]. Chin J Cancer Res, 2024, 36(5):489-502. |
| [17] | 中华医学会肿瘤学分会早诊早治学组, 苗智峰, 徐忠法, 等. 胃癌早诊早治中国专家共识(2023版)[J]. 中华消化外科杂志, 2024, 23(1):23-36. |
| Early Diagnosis and Treatment Group, Chinese Society of Oncology, Chinese Medical Association, Miao ZF, Xu ZF, et al. Chinese expert consensus on early diagnosis and treatment of gastric cancer (2023 edition)[J]. Chin J Dig Surg, 2024, 23(1): 23-36. | |
| [18] | 杨鋆, 辛城霖, 张忠涛. 中低位直肠癌的精准诊断与规范治疗[J]. 中华消化外科杂志, 2024, 23(1):85-90. |
| YANG Y, XIN C L, ZHANG Z T. Precision diagnosis and standardized treatment of midlow rectal cancer[J]. Chin J Dig Surg, 2024, 23(1): 85-90. | |
| [19] | FENG Q X, LIU C, QI L, et al. An intelligent clinical decision support system for preoperative prediction of lymph node metastasis in gastric cancer[J]. J Am Coll Radiol, 2019, 16(7):952-960. |
| [20] | GAO Y, ZHANG Z D, LI S, et al. Deep neural network-assisted computed tomography diagnosis of metastatic lymph nodes from gastric cancer[J]. Chin Med J (Engl), 2019, 132(23):2804-2811. |
| [21] | LIU Y, CHEN L, FAN M, et al. Application of AI-assisted MRI for the identification of surgical target areas in pediatric hip and periarticular infections[J]. BMC Musculoskelet Disord, 2024, 25(1):428. |
| [22] | YANG R, YAN C, LU S, et al. Tracking cancer lesions on surgical samples of gastric cancer by artificial intelligent algorithms[J]. J Cancer, 2021, 12(21):6473-6483. |
| [23] | MA B, GUO Y, HU W, et al. Artificial intelligence-based multiclass classification of benign or malignant mucosal lesions of the stomach[J]. Front Pharmacol, 2020, 11:572372. |
| [24] | TUNG C L, CHANG H C, YANG B Z, et al. Identifying pathological slices of gastric cancer via deep learning[J]. J Formos Med Assoc, 2022, 121(12):2457-2464. |
| [25] | ZHU M, GUO M, LIU C Q, et al. Deep-learning model AIBISI predicts bacterial infection across cancer types based on pathological images[J]. Heliyon, 2023, 9(4):e15400. |
| [26] | 姚金玉, 卢庆苗, 鲁一兵. 甲状腺类器官研究进展[J]. 中华内分泌代谢杂志, 2024, 40(1):73-76. |
| YAO J Y, LU Q M, LU Y B. Advances in the research of thyroid organoid[J]. Chin J Endocrinol Metab, 2024, 40(1):73-76. | |
| [27] | 黄立颖, 张欢, 李裕明, 等. 胃肠内分泌细胞分化和功能研究进展[J]. 中华内分泌代谢杂志, 2024, 40(6):538-544. |
| HUANG L Y, ZHANG H, LI Y M. Enteroendocrine cell differentiation and function: An update[J]. Chin J Endocrinol Metab, 2024, 40(6):538-544. | |
| [28] | BIAN X, LI G, WANG C, et al. A deep learning model for detection and tracking in high-throughput images of organoid[J]. Comput Biol Med, 2021, 134:104490. |
| [29] | KASSIS T, HERNANDEZ-GORDILLO V, LANGER R, et al. OrgaQuant: Human intestinal organoid localization and quantification using deep convolutional neural networks[J]. Sci Rep, 2019, 9(1):12479. |
| [30] | YANG R, DU Y, KWAN W, et al. A quick and reliable image-based AI algorithm for evaluating cellular senescence of gastric organoids[J]. Cancer Biol Med, 2023, 20(7):519-536. |
| [31] | OKAMOTO T, NATSUME Y, DOI M, et al. Integration of human inspection and artificial intelligence-based morphological typing of patient-derived organoids reveals interpatient heterogeneity of colorectal cancer[J]. Cancer Sci, 2022, 113(8):2693-2703. |
| [32] | 田捷, 王坤, 董迪, 等. 基于人工智能和医疗大数据的肿瘤荧光手术导航与量化评估策略[J]. 中华消化外科杂志, 2024, 23(4):536-542. |
| TIAN J, WANG K, DONG D, et al. Navigation and quantitative evaluation strategies for tumor fluorescent surgery based on artificial intelligence and medical big data[J]. Chin J Dig Surg, 2024, 23(4): 536-542. |
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