诊断学理论与实践

诊断学理论与实践 >

2026 , Vol. 25 >Issue 03: 287 - 307

DOI: https://doi.org/10.16150/j.1671-2870.2026.03.005

论著

2025年中国华东地区真菌耐药监测报告

  • 林慧萍 ,
  • 王东江 ,
  • 郭建 ,
  • 李腾 ,
  • 杨思敏 ,
  • 王莎莎 ,
  • 周爱萍 ,
  • 胡靓 ,
  • 田文杰 ,
  • 麻浙效 ,
  • 吴家棋 ,
  • 古丽孜巴·亚力买买提 ,
  • 张燕 ,
  • 陈会 ,
  • 萧晨路 ,
  • 郭玮 ,
  • 王苏珍 ,
  • 万智敏 ,
  • 韩春华 ,
  • 王盛华 ,
  • 温开镇 ,
  • 李彬 ,
  • 陈燕林 ,
  • 谢屿平 ,
  • 陈雯静 ,
  • 孟红委 ,
  • 李志夫 ,
  • 徐和平 ,
  • 何磊 ,
  • 魏慕筠 ,
  • 李婷华 ,
  • 杨海慧 ,
  • 奚卫 ,
  • 吴永琴 ,
  • 鲁怀伟 ,
  • 庄亦晖 ,
  • 刘研 ,
  • 沈丹丹 ,
  • 秦洁 ,
  • 李晟超 ,
  • 杨青 ,
  • 黄晶晶 ,
  • 唐朝贵 ,
  • 徐杰 ,
  • 任建敏 ,
  • 刘淑芬 ,
  • 胡秀华 ,
  • 商安全 ,
  • 袁轶群 ,
  • 周玲 ,
  • 邓卫平 ,
  • 陈思佳 ,
  • 胡海清 ,
  • 鹿秀海 ,
  • 胡永奇 ,
  • 李志兰 ,
  • 戴芸 ,
  • 胡妮娅 ,
  • 曾令兵 ,
  • 钱敏建 ,
  • 黄晓春 ,
  • 潘芬 ,
  • 蒋娜 ,
  • 胡娟 ,
  • 朱召芹 ,
  • 金英 ,
  • 杨乐园 ,
  • 刘淮玉 ,
  • 李妮娅 ,
  • 翁丽贞 ,
  • 夏益兰 ,
  • 李娜 ,
  • 高晶 ,
  • 张晓雪 ,
  • 刘云 ,
  • 陈旭 ,
  • 戴俊华 ,
  • 刘军 ,
  • 钱朵朵 ,
  • 侯伟伟 ,
  • 王月玲 ,
  • 孙静芳 ,
  • 黄莉莉 ,
  • 舒文 ,
  • 李丽 ,
  • 时建英 ,
  • 张灏旻 ,
  • 刘春红 ,
  • 杨卫华 ,
  • 王芳 ,
  • 吴文娟
展开
  • 1 上海市东方医院（同济大学附属东方医院）南院检验科，上海 200123
    2 南京大学医学院附属鼓楼医院检验科，江苏 南京 210008
    3 江西省人民医院检验科，江西 南昌 330000
    4 上海交通大学医学院附属瑞金医院检验科，上海 200025
    5 复旦大学附属中山医院检验科，上海 200032
    6 湖南省人民医院（湖南师范大学附属第一医院）检验科，湖南 长沙 410005
    7 青岛大学附属医院检验科，山东 青岛 266000
    8 山东省立医院中心院区检验科，山东 济南 250021
    9 福建省晋江市医院检验科，福建 晋江 362200
    10 福建医科大学附属协和医院检验科，福建 福州 350001
    11 上海市第一人民医院检验科，上海 200080
    12 上海市胸科医院检验科，上海 200030
    13 厦门大学附属第一医院检验科，福建 厦门 361003
    14 上海交通大学医学院附属仁济医院西院检验科，上海 200001
    15 上海交通大学医学院附属仁济医院南院检验科，上海 201112
    16 中国科学技术大学附属第一医院（安徽省立医院）检验科，安徽 合肥 230001
    17 复旦大学附属肿瘤医院检验科，上海 200032
    18 上海市第十人民医院检验科，上海 200072
    19 复旦大学附属儿科医院检验科，上海 201102
    20 浙江大学医学院附属第一医院检验科，浙江 杭州 310003
    21 淮安市第一人民医院检验科，江苏 淮安 223300
    22 苏州大学附属第一医院检验科，江苏苏州 215006
    23 浙江省丽水市中心医院检验科，浙江丽水 323000
    24 上海市浦东新区周浦医院检验科，上海 201318
    25 连云港市第二人民医院检验科，江苏 连云港 222023
    26 复旦大学附属金山医院检验科，上海 201508
    27 上海市浦东医院检验科，上海 201399
    28 上海东方肝胆外科医院检验科，上海 200438
    29 海军军医大学第二附属医院（上海长征医院）检验科，上海 200003
    30 山东省眼科医院检验科，山东 济南 250021
    31 上海市同仁医院检验科，上海 200336
    32 上海市第七人民医院检验科，上海 200137
    33 上海中医药大学附属曙光医院检验科，上海 200021
    34 南昌大学第一附属医院检验科，江西 南昌 330006
    35 上海健康医学院附属崇明医院检验科，上海 202150
    36 上海长海医院检验科，上海 200433
    37 上海市儿童医院检验科，上海 200062
    38 上海市浦东新区公利医院检验科，上海 200135
    39 上海市第五人民医院检验科，上海 200240
    40 上海市公共卫生临床中心检验科，上海 200083
    41 上海市浦东新区浦南医院南院检验科，上海 200125
    42 上海市宝山区中西医结合医院检验科，上海 201999
    43 上海市第六人民医院检验科，上海 200233
    44 上海市第六人民医院临港院区检验科，上海 201306
    45 上海市静安区中心医院检验科，上海 200040
    46 中国人民解放军海军特色医学中心检验科，上海 200052
    47 复旦大学附属妇产科医院检验科，上海 200090
    48 上海市浦东新区人民医院检验科，上海 201299
    49 上海中医药大学附属岳阳中西医结合医院检验科，上海 200437
    50 上海交通大学医学院附属第九人民医院检验科，上海 200011
    51 上海市普陀区中心医院检验科，上海 200333
    52 上海市松江区中心医院检验科，上海 201600
    53 上海市杨浦区中心医院检验科，上海 200090
    54 上海市同济医院检验科，上海 200065
    55 山东省立医院东院区检验科，山东 济南 250014
    56 徐州医科大学附属医院检验科，江苏 徐州 221000
    57 苏州大学附属儿童医院检验科，江苏 苏州 215025
    58 上海市第一人民医院南院检验科，上海 201620
    59 上海交通大学医学院附属瑞金医院检验科，上海 200025
    60 上海市嘉定区中心医院检验科，上海 201800
    61 上海交通大学医学院附属仁济医院东院检验科，上海 200127
    62 复旦大学附属眼耳鼻喉科医院检验科，上海 200031
    63 上海市静安区闸北中心医院检验科，上海 200070
    64 复旦大学附属中山医院青浦院区检验科，上海 201700
吴文娟 E-mail：wwj1210@126.com

收稿日期: 2026-03-02

  修回日期: 2026-05-13

  录用日期: 2026-05-18

  网络出版日期: 2026-06-27

基金资助

国家自然科学基金(82572595);国家自然科学基金国际（地区）合作与交流项目(W2411075);国家重点研发计划(2024YFC2309600)

收起

Fungal resistance surveillance report in East China in 2025

  • LIN Huiping ,
  • WANG Dongjiang ,
  • GUO Jian ,
  • LI Teng ,
  • YANG Simin ,
  • WANG Shasha ,
  • ZHOU Aiping ,
  • HU Liang ,
  • TIAN Wenjie ,
  • MA Zhexiao ,
  • WU Jiaqi ,
  • GULIZIBA Yalimaimaiti ,
  • ZHANG Yan ,
  • CHEN Hui ,
  • XIAO Chenlu ,
  • GUO Wei ,
  • WANG Suzhen ,
  • WAN Zhimin ,
  • HAN Chunhua ,
  • WANG Shenghua ,
  • WEN Kaizhen ,
  • LI Bin ,
  • CHEN Yanlin ,
  • XIE Yuping ,
  • CHEN Wenjing ,
  • MENG Hongwei ,
  • LI Zhifu ,
  • XU Heping ,
  • HE Lei ,
  • WEI Muyun ,
  • LI Tinghua ,
  • YANG Haihui ,
  • XI Wei ,
  • WU Yongqin ,
  • LU Huaiwei ,
  • ZHUANG Yihui ,
  • LIU Yan ,
  • SHEN Dandan ,
  • QIN Jie ,
  • LI Shengchao ,
  • YANG Qing ,
  • HUANG Jingjing ,
  • TANG Chaogui ,
  • XU Jie ,
  • REN Jianmin ,
  • LIU Shufen ,
  • HU Xiuhua ,
  • SHANG Anquan ,
  • YUAN Yiqun ,
  • ZHOU Ling ,
  • DENG Weiping ,
  • CHEN Sijia ,
  • HU Haiqing ,
  • LU Xiuhai ,
  • HU Yongqi ,
  • LI Zhilan ,
  • DAI Yun ,
  • HU Niya ,
  • ZENG Lingbing ,
  • QIAN Minjian ,
  • HUANG Xiaochun ,
  • PAN Fen ,
  • JIANG Na ,
  • HU Juan ,
  • ZHU Zhaoqin ,
  • JIN Ying ,
  • YANG Leyuan ,
  • LIU Huaiyu ,
  • LI Niya ,
  • WENG Lizhen ,
  • XIA Yilan ,
  • LI Na ,
  • GAO Jing ,
  • ZHANG Xiaoxue ,
  • LIU Yun ,
  • CHEN Xu ,
  • DAI Junhua ,
  • LIU Jun ,
  • QIAN Duoduo ,
  • HOU Weiwei ,
  • WANG Yueling ,
  • SUN Jingfang ,
  • HUANG Lili ,
  • SHU Wen ,
  • LI Li ,
  • SHI Jianying ,
  • ZHANG Haomin ,
  • LIU Chunhong ,
  • YANG Weihua ,
  • WANG Fang ,
  • WU Wenjuan
Expand
  • 1 Department of Clinical Laboratory, South Campus of Shanghai East Hospital (The Affiliated East Hospital of Tongji University), Shanghai 200123, China
    2 Department of Clinical Laboratory, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing 210008, Jiangsu, China
    3 Department of Clinical Laboratory, Jiangxi Provincial People's Hospital, Nanchang 330000, Jiangxi, China
    4 Department of Clinical Laboratory, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    5 Department of Clinical Laboratory, Zhongshan Hospital Affiliated to Fudan University, Shanghai 200032, China
    6 Department of Clinical Laboratory, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha 410005, Hunan, China
    7 Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong, China
    8 Department of Clinical Laboratory, Central Campus of Shandong Provincial Hospital, Jinan 250021, Shandong, China
    9 Department of Clinical Laboratory, Jinjiang Hospital of Fujian Province, Jinjiang 362200, Fujian, China
    10 Department of Clinical Laboratory, Union Hospital Affiliated to Fujian Medical University, Fuzhou 350001, Fujian, China
    11 Department of Clinical Laboratory, Shanghai General Hospital, Shanghai 200080, China
    12 Department of Clinical Laboratory, Shanghai Chest Hospital, Shanghai 200030, China
    13 Department of Clinical Laboratory, The First Affiliated Hospital of Xiamen University, Xiamen 361003, Fujian, China
    14 Department of Clinical Laboratory, West Campus of Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China
    15 Department of Clinical Laboratory, South Campus of Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 201112, China
    16 Department of Clinical Laboratory, The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei 230001, Anhui, China
    17 Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, Shanghai 200032, China
    18 Department of Clinical Laboratory, Shanghai Tenth People's Hospital, Shanghai 200072, China
    19 Department of Clinical Laboratory, Children's Hospital of Fudan University, Shanghai 201102, China
    20 Department of Clinical Laboratory, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang, China
    21 Department of Clinical Laboratory, The First People's Hospital of Huai'an, Huai'an 223300, Jiangsu, China
    22 Department of Clinical Laboratory, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu, China
    23 Department of Clinical Laboratory, Lishui Central Hospital of Zhejiang Province, Lishui 323000, Zhe-jiang, China
    24 Department of Clinical Laboratory, Zhoupu Hospital of Pudong New Area, Shanghai 201318, China
    25 Department of Clinical Laboratory, The Second People's Hospital of Lianyungang, Lianyungang 222023, Jiangsu, China
    26 Department of Clinical Laboratory, Jinshan Hospital Affiliated to Fudan University, Shanghai 201508, China
    27 Department of Clinical Laboratory, Shanghai Pudong Hospital, Shanghai 201399, China
    28 Department of Clinical Laboratory, Eastern Hepatobiliary Surgery Hospital, Shanghai 200438, China
    29 Department of Clinical Laboratory, The Second Affiliated Hospital of Naval Medical University (Shanghai Changzheng Hospital), Shanghai 200003, China
    30 Department of Clinical Laboratory, Shandong Eye Hospital, Jinan 250021, Shandong, China
    31 Department of Clinical Laboratory, Shanghai Tongren Hospital, Shanghai 200336, China
    32 Department of Clinical Laboratory, Shanghai Seventh People's Hospital, Shanghai 200137, China
    33 Department of Clinical Laboratory, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China
    34 Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China
    35 Department of Clinical Laboratory, Chongming Hospital Affilia-ted to Shanghai University of Medicine and Health Sciences, Shanghai 202150, China
    36 Department of Clinical Laboratory, Changhai Hospital, Shanghai 200433, China
    37 Department of Clinical Laboratory, Shanghai Children's Hospital, Shanghai 200062, China
    38 Department of Clinical Laboratory, Gongli Hospital of Pudong New Area, Shanghai 200135, China
    39 Department of Clinical Laboratory, The Fifth People's Hospital of Shanghai, Shanghai 200240, China
    40 Department of Clinical Laboratory, Shanghai Public Health Clinical Center, Shanghai 200083, China
    41 Department of Clinical Laboratory, South Campus of Punan Hospital of Pudong New Area, Shanghai 200125, China
    42 Department of Clinical Laboratory, Baoshan Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai 201999, China
    43 Department of Clinical Laboratory, Shanghai Sixth People's Hospital, Shanghai 200233, China
    44 Department of Clinical Laboratory, Lingang Campus of Shanghai Sixth People's Hospital, Shanghai 201306, China
    45 Department of Clinical Laboratory, Jing'an District Central Hospital of Shanghai, Shanghai 200040, China
    46 Department of Clinical Laboratory, Naval Special Medical Center of PLA, Shanghai 200052, China
    47 Department of Clinical Laboratory, Obstetrics and Gynecology Hospital Affiliated to Fudan University, Shanghai 200090, China
    48 Department of Clinical Laboratory, People's Hospital of Pudong New Area, Shanghai 201299, China
    49 Department of Clinical Laboratory, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
    50 Department of Clinical Laboratory, The Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
    51 Department of Clinical Laboratory, Putuo District Central Hospital of Shanghai, Shanghai 200333, China
    52 Department of Clinical Laboratory, Songjiang District Central Hospital of Shanghai, Shanghai 201600, China
    53 Department of Clinical Laboratory, Yangpu District Central Hospital of Shanghai, Shanghai 200090, China
    54 Department of Clinical Laboratory, Tongji Hospital of Shanghai, Shanghai 200065, China
    55 Department of Clinical Laboratory, East Campus of Shandong Provincial Hospital, Jinan 250014, Shandong, China
    56 Department of Clinical Laboratory, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221000, Jiangsu, China
    57 Department of Clinical Laboratory, Children's Hospital of Soochow University, Suzhou 215025, Jiangsu, China
    58 Department of Clinical Laboratory, South Campus of Shanghai General Hospital, Shanghai 201620, China
    59 Department of Clinical Laboratory, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    60 Department of Clinical Laboratory, Jiading District Central Hospital of Shanghai, Shanghai 201800, China
    61 Department of Clinical Laboratory, East Campus of Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
    62 Department of Clinical Laboratory, Eye and ENT Hospital Affiliated to Fudan University, Shanghai 200031, China
    63 Department of Clinical Laboratory, Zhabei Central Hospital of Jing'an District, Shanghai 200070, China
    64 Department of Clinical Laboratory, Qingpu Campus of Zhongshan Hospital Affiliated to Fudan University, Shanghai 201700, China

Received date: 2026-03-02

  Revised date: 2026-05-13

  Accepted date: 2026-05-18

  Online published: 2026-06-27

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摘要

目的：监测2025年中国华东地区临床分离真菌的抗真菌药物敏感性情况，为临床诊断和治疗提供参考。方法：回顾性分析2025年1月至12月华东地区侵袭性真菌感染协作组（Eastern China Invasive Fungi Infection Group， ECIFIG）收集的临床真菌，采用形态学结合质谱检测对菌种进行鉴定，结合内转录间隔区测序和β微管蛋白基因测序技术对结果进行复核。采用微量肉汤稀释法进行抗真菌药物（唑类药物，包括氟康唑、伊曲康唑、伏立康唑、泊沙康唑和艾沙康唑；棘白菌素类药物，包括米卡芬净、阿尼芬净和卡泊芬净；两性霉素B和氟胞嘧啶）的药敏试验。结果：2025年，华东地区共收集酵母菌2 044株，血液为主要标本类型，占37.06%（763/2044）；白念珠菌占比38.51%（793/2044），热带念珠菌占比18.89%（389/2044），近平滑念珠菌占比16.61%（342/2044），光滑念珠菌占比15.20%（313/2044），克柔念珠菌占比1.75%（36/2044）。2025年，华东地区共收集丝状真菌310株，主要为曲霉，包括烟曲霉（62.26%）、黄曲霉（26.45%）、黑曲霉（5.81%）和土曲霉（3.55%）；丝状真菌主要分离自呼吸道标本，其中痰液标本占比53.23%，肺泡灌洗液标本占比31.29%。念珠菌的耐药性主要表现为对唑类耐药，白念珠菌对氟康唑耐药率为3.66%，泊沙康唑非野生型菌株占比为6.81%。热带念珠菌对氟康唑耐药率为29.05%，对伏立康唑非敏感菌株为24.45%，伊曲康唑非野生型菌株占比为17.48%，泊沙康唑非野生型菌株占比为61.18%；近平滑念珠菌对氟康唑耐药率为11.7%，两性霉素B非野生型菌株占比为2.30%；光滑念珠菌对氟康唑耐药率为5.75%；伊曲康唑、泊沙康唑、伏立康唑非野生型菌株占比分别为1.92%、12.78%、28.12%。烟曲霉对伏立康唑的中介率为3.63%，耐药率为5.18%，艾沙康唑中介率为1.04%，耐药率为4.70%，对伊曲康唑的非野生型比率为3.11%；黄曲霉对卡泊芬净、两性霉素B和唑类药物均为野生型菌株。结论：2025年，中国华东地区真菌监测网共收集酵母菌2 044株，主要分离自血液标本，白念珠菌占比最高；共收集丝状真菌310株，主要分离自呼吸道标本，烟曲霉占比最高。热带念珠菌对唑类药物耐药性明显高于其他念珠菌种；烟曲霉对唑类耐药率为5.18%，较往年有所升高；未发现黄曲霉唑类耐药菌株。

关键词： 中国华东地区; 真菌耐药性监测; 侵袭性真菌感染; 抗真菌药物敏感性试验

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林慧萍 , 王东江 , 郭建 , 李腾 , 杨思敏 , 王莎莎 , 周爱萍 , 胡靓 , 田文杰 , 麻浙效 , 吴家棋 , 古丽孜巴·亚力买买提 , 张燕 , 陈会 , 萧晨路 , 郭玮 , 王苏珍 , 万智敏 , 韩春华 , 王盛华 , 温开镇 , 李彬 , 陈燕林 , 谢屿平 , 陈雯静 , 孟红委 , 李志夫 , 徐和平 , 何磊 , 魏慕筠 , 李婷华 , 杨海慧 , 奚卫 , 吴永琴 , 鲁怀伟 , 庄亦晖 , 刘研 , 沈丹丹 , 秦洁 , 李晟超 , 杨青 , 黄晶晶 , 唐朝贵 , 徐杰 , 任建敏 , 刘淑芬 , 胡秀华 , 商安全 , 袁轶群 , 周玲 , 邓卫平 , 陈思佳 , 胡海清 , 鹿秀海 , 胡永奇 , 李志兰 , 戴芸 , 胡妮娅 , 曾令兵 , 钱敏建 , 黄晓春 , 潘芬 , 蒋娜 , 胡娟 , 朱召芹 , 金英 , 杨乐园 , 刘淮玉 , 李妮娅 , 翁丽贞 , 夏益兰 , 李娜 , 高晶 , 张晓雪 , 刘云 , 陈旭 , 戴俊华 , 刘军 , 钱朵朵 , 侯伟伟 , 王月玲 , 孙静芳 , 黄莉莉 , 舒文 , 李丽 , 时建英 , 张灏旻 , 刘春红 , 杨卫华 , 王芳 , 吴文娟 . 2025年中国华东地区真菌耐药监测报告[J]. 诊断学理论与实践, 2026 , 25(03) : 287 -307 . DOI: 10.16150/j.1671-2870.2026.03.005

Abstract

Objective This study aims to monitor the antifungal susceptibility of clinically isolated fungi in East China in 2025, thereby providing a reference for clinical diagnosis and treatment. Methods A retrospective analysis was conducted on clinical fungi collected by the East China Invasive Fungal Infection Group (ECIFIG) from January to December 2025. Species identification was performed using morphological characteristics combined with mass spectrometry, and the results were verified by internal transcribed spacer (ITS) sequencing and β-tubulin gene sequencing. Antifungal susceptibility testing for azoles (fluconazole, itraconazole, voriconazole, posaconazole, isavuconazole), echinocandins (micafungin, anidulafungin, caspofungin), amphotericin B, and flucytosine was carried out using the broth microdilution method. Results In 2025, a total of 2 044 yeast isolates were collected in East China, and blood was the primary specimen type, accounting for 37.06% (763/2 044). The yeast species distribution was as follows: Candida albicans 38.51% (793/2 044), Candida tropicalis 18.89% (389/2 044), Candida parapsilosis 16.61% (342/2 044), Candida glabrata 15.20% (313/2 044), and Candida krusei 1.75% (36/2 044). A total of 310 filamentous fungal isolates were collected in East China, predominantly Aspergillus species: Aspergillus fumigatus (62.26%), Aspergillus flavus (26.45%), Aspergillus niger (5.81%), and Aspergillus terreus (3.55%). Filamentous fungi were mainly isolated from respiratory specimens, with sputum specimen accounting for 53.23% and bronchoalveolar lavage fluid (BALF) specimen accounting for 31.29%. Resistance in Candida species was primarily observed for azoles. The fluconazole resistance rate in C. albicans was 3.66%, and the rate of non-wild-type (NWT) isolates for posaconazole was 6.81%. For C. tropicalis, the fluconazole resistance rate was 29.05%, the voriconazole non-susceptible rate was 24.45%, the itraconazole NWT rate was 17.48%, and the posaconazole NWT rate was 61.18%. C. parapsilosis showed a fluconazole resistance rate of 11.7% and an amphotericin B NWT rate of 2.30%. C. glabrata exhibited a fluconazole resistance rate of 5.75%, and the NWT rates for itraconazole, posaconazole, and voriconazole were 1.92%, 12.78%, and 28.12%, respectively. For A. fumigatus, the voriconazole intermediate rate was 3.63%, and the resistance rate was 5.18%. The isavuconazole intermediate rate was 1.04%, the resistance rate was 4.70%, and the NWT rate for itraconazole was 3.11%. All A. flavus isolates were wild-type for caspofungin, amphotericin B, and azoles. Conclusions In 2025, East China Fungal Surveillance Network collects 2 044 yeast isolates, primarily from blood specimens, with C. albicans being the most prevalent. A total of 310 filamentous fungal isolates are collected, mainly from respiratory specimens, with A. fumigatus being the most common. Azole resistance in C. tropicalis is significantly higher than that in other Candida species. The azole resistance rate in A. fumigatus is 5.18%, showing an increase compared to it in previous years. No azole-resistant A. flavus isolates have been detected.

Key words： East China; Fungal resistance surveillance; Invasive fungal infection; Antifungal susceptibility testing

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