Journal of Diagnostics Concepts & Practice >

2025 , Vol. 24 >Issue 05: 498 - 504

DOI: https://doi.org/10.16150/j.1671-2870.2025.05.004

Original articles

Comparative study on diagnostic performance of Acquire fine-needle biopsy and fine-needle aspiration in endoscopic ultrasonography-guided tissue acquisition for type 1 autoimmune pancreatitis

  • SHEN Xiaonan ,
  • ZHOU Chunhua ,
  • ZHANG Benyan ,
  • GAO Lili ,
  • ZHANG Ling ,
  • HE Xiangyi ,
  • LIU Chenxiao ,
  • ZHANG Xianda ,
  • ZHANG Yao ,
  • WU Wei ,
  • GONG Tingting ,
  • ZHANG Tianyu ,
  • LIU Lei ,
  • ZOU Duowu ,
  • ZHANG Minmin
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  • Department of Gastroenterology; b. Department of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Received date: 2025-06-19

  Revised date: 2025-07-25

  Accepted date: 2025-07-30

  Online published: 2025-10-25

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Abstract

Objective： To compare the application value of 22G-Acquire fine-needle biopsy (FNB) and conventional 22G fine-needle aspiration (FNA) in the cytological diagnosis of type 1 autoimmune pancreatitis (AIP). Methods： This retrospective study included 57 patients who were highly suspected of type 1 AIP based on imaging and serology and were admitted to our hospital from January 2020 to January 2024. According to the type of needle used, patients were divided into two groups: the FNB group (22G-Acquire needle, n=30) and the FNA group (n=27) to evaluate the histological diagnostic levels of type 1 AIP obtained by two needle types under endoscopic ultrasonography (EUS)-guided sampling. Results： In the FNA group, lymphoplasmacytic infiltration was observed in 33.3% of puncture tissues, while storiform fibrosis was identified in only 22.2%. Level 2 histological evidence was achieved in 11.1% of cases, with no Level 1 evidence. In the FNB group, lymphoplasmacytic infiltration was observed in 63.3% of puncture tissues, and storiform fibrosis was present in 83.3% of puncture tissues. Level 1 evidence was observed in 3.3% of cases, Level 2 in 56.7%, and combined Level 1+2 in 60%. Obliterative phlebitis was not detected in either group. Two cases met the criteria of IgG4-positive plasma cells >10 per high power field (HPF), with 1 case each in FNB group and FNA group. Compared to the FNA group, the FNB group showed significant advantages in the detection of lymphoplasmacytic infiltration (63.3% vs 33.3%) (P=0.024) and storiform fibrosis (83.3% vs 22.2%) (P<0.001) in the obtained tissues, along with higher evidence levels (P<0.001). Conclusion： The 22G-Acquire needle can obtain higher tissue evidence levels and can be routinely employed for the histological diagnosis of type 1 AIP.

Key words： Type 1 autoimmune pancreatitis; Fine-needle biopsy; Fine-needle aspiration; Histopathological diagnosis

Cite this article

SHEN Xiaonan , ZHOU Chunhua , ZHANG Benyan , GAO Lili , ZHANG Ling , HE Xiangyi , LIU Chenxiao , ZHANG Xianda , ZHANG Yao , WU Wei , GONG Tingting , ZHANG Tianyu , LIU Lei , ZOU Duowu , ZHANG Minmin . Comparative study on diagnostic performance of Acquire fine-needle biopsy and fine-needle aspiration in endoscopic ultrasonography-guided tissue acquisition for type 1 autoimmune pancreatitis[J]. Journal of Diagnostics Concepts & Practice, 2025 , 24(05) : 498 -504 . DOI: 10.16150/j.1671-2870.2025.05.004

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