三种ADAMTS13去整合素样结构域突变致蛋白功能缺陷及其与血栓关联的研究

林莉亚, 吴希, 毛胤祺, 陈光明, 武文漫, 戴菁, 王学锋, 丁秋兰

Three disintegrin-like domain mutations of ADAMTS13： functional deficiency and association with thrombosis

LIN Liya, WU Xi, MAO Yinqi, CHEN Guangming, WU Wenman, DAI Jing, WANG Xuefeng, DING Qiulan

图3 vWF多聚体分析结果 A：vWF多聚体电泳，泳道1（NP）为正常血浆；泳道2-5（P1-P4）为4名先证者血浆。B：vWF多聚体电泳图灰度值半定量分析。C：vWF HMWMs半定量结果统计。HMWMs：高分子量多聚体。IMWMs：中分子量多聚体。LMWMs：低分子量多聚体。与NP比较，**： P<0.01；***： P<0.001；****： P<0.000 1。

Figure 3 Results of vWF multimer analysis A: vWF polymer electrophoress. Lane 1 (NP): normal plasma; lanes 2-5 (P1-P4): plasma from 4 probands. B: Semi-quantitative analysis of the grayscale values of vWF polymer electrophoresis images. C: Semi-quantitative results of vWF HMWMs statistical analysis. HMWMs: High molecular weight polymers. IMWMs: Intermediate molecular weight polymers. LMWMs: Low molecular weight polymers. **: P<0.01 vs NP. ***: P<0.001 vs NP. ****: P<0.000 1 vs NP.