内科理论与实践 ›› 2026, Vol. 21 ›› Issue (01): 91-97.doi: 10.16138/j.1673-6087.2026.01.14
收稿日期:2024-11-20
出版日期:2026-02-25
发布日期:2026-04-08
通讯作者:
李慧凛 E-mail:medlhl@163.com
基金资助:
YANG Dongminga, LI Huilinb,*(
)
Received:2024-11-20
Online:2026-02-25
Published:2026-04-08
Contact:
Li Huilin,Email:摘要:
类风湿关节炎合并肌少症在临床上较为常见,肌少症在类风湿关节炎患者中的发病率较高。随着类风湿关节炎病情的进展,肌少症的发展也会加速,增加患者功能障碍、失能、跌倒、衰弱以及死亡的风险,严重降低其生活质量。两者相互影响并互相加重。营养不良是肌少症的重要原因,类风湿关节炎患者常存在不同程度的营养不良、贫血及免疫功能低下,尤其多见于老年人。本文从膳食营养干预的角度综述类风湿关节炎合并肌少症的治疗方法,旨在提高临床医师对该病的认识,并为相关营养防治提供参考。
中图分类号:
杨东明, 李慧凛. 类风湿关节炎合并肌少症的营养治疗[J]. 内科理论与实践, 2026, 21(01): 91-97.
YANG Dongming, LI Huilin. Nutritional therapy for sarcopenia in rheumatoid arthritis patients[J]. Journal of Internal Medicine Concepts & Practice, 2026, 21(01): 91-97.
| [1] | Rosenberg I. Epidemiologic and methodologic problems in determining nutritional status of older persons[J]. Am J Clin Nutr,1989,50 Suppl 5: S1121-S1235. |
| [2] |
Cruz-Jentoft AJ, Baeyens JP, Bauer JM, et al. Sarcopenia: European consensus on definition and diagnosis: report of the European working group on sarcopenia in older people[J]. Age Ageing, 2010, 39(4):412-423.
doi: 10.1093/ageing/afq034 |
| [3] |
Chen LK, Liu LK, Woo J, et al. Sarcopenia in Asia: consensus report of the Asian working group for sarcopenia[J]. J Am Med Dir Assoc, 2014, 15(2):95-101.
doi: 10.1016/j.jamda.2013.11.025 |
| [4] |
Anker SD, Morley JE, von Haehling S. Welcome to the ICD-10 code for sarcopenia[J]. J Cachexia Sarcopenia Muscle, 2016, 7(5):512-514.
doi: 10.1002/jcsm.12147 |
| [5] |
Cruz-Jentoft AJ, Sayer AA. Sarcopenia[J]. Lancet, 2019, 393(10191):2636-2646.
doi: 10.1016/S0140-6736(19)31138-9 |
| [6] |
Cruz-Jentoft AJ, Bahat G, Bauer J, et al. Sarcopenia: revised European consensus on definition and diagnosis[J]. Age Ageing, 2019, 48(1):16-31.
doi: 10.1093/ageing/afy169 |
| [7] |
Cannataro R, Carbone L, Petro JL, et al. Sarcopenia: etiology, nutritional approaches, and miRNAs[J]. Int J Mol Sci, 2021, 22(18):9724.
doi: 10.3390/ijms22189724 |
| [8] |
Chen LK, Woo J, Assantachai P, et al. Asian working group for sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment[J]. J Am Med Dir Assoc, 2020, 21(3):300-307.
doi: 10.1016/j.jamda.2019.12.012 |
| [9] |
Tański W, Wójciga J, Jankowska-Polańska B. Association between malnutrition and quality of life in elderly patients with rheumatoid arthritis[J]. Nutrients, 2021, 13(4):1259.
doi: 10.3390/nu13041259 |
| [10] |
黄蓓, 刘隆福, 蒋铁建. 糖皮质激素与肌少症[J]. 中华骨质疏松和骨矿盐疾病杂志, 2020, 13(5):486-492.
doi: 10.3969/j.issn.1674-2591.2020.05.014 |
|
Huang B, Liu LF, Jiang TJ. Glucocorticoid and sarcopenia[J]. Chin J Osteoporos Bone Miner Res, 2020, 13(5):486-492.
doi: 10.3969/j.issn.1674-2591.2020.05.014 |
|
| [11] |
Torii M, Hashimoto M, Hanai A, et al. Prevalence and factors associated with sarcopenia in patients with rheumatoid arthritis[J]. Mod Rheumatol, 2019, 29(4):589-595.
doi: 10.1080/14397595.2018.1510565 |
| [12] |
Alkan Melikoğlu M. Presarcopenia and its impact on disability in female patients with rheumatoid arthritis[J]. Arch Rheumatol, 2017, 32(1):53-59.
doi: 10.5606/ArchRheumatol.2017.6078 |
| [13] |
Ngeuleu A, Allali F, Medrare L, et al. Sarcopenia in rheumatoid arthritis: prevalence, influence of disease activity and associated factors[J]. Rheumatol Int, 2017, 37(6):1015-1020.
doi: 10.1007/s00296-017-3665-x |
| [14] | 赵亚菲, 潘文萍, 王占奎. 类风湿关节炎合并肌少症的研究进展[J]. 风湿病与关节炎, 2023, 12(8):65-70. |
| Zhao YF, Pan WP, Wang ZK. Research advances in rheumatoid arthritis with comorbid sarcopenia[J]. Rheumatism and Arthritis, 2023, 12(8):65-70. | |
| [15] |
Dalle S, Koppo K. Is inflammatory signaling involved in disease-related muscle wasting? Evidence from osteoarthritis, chronic obstructive pulmonary disease and type Ⅱ diabetes[J]. Exp Gerontol, 2020, 137:110964.
doi: 10.1016/j.exger.2020.110964 |
| [16] |
van Bokhorst-de van der Schueren MA, Konijn NP, Bultink IE, et al. Relevance of the new pre-cachexia and cachexia definitions for patients with rheumatoid arthritis[J]. Clin Nutr, 2012, 31(6):1008-1010.
doi: 10.1016/j.clnu.2012.05.012 |
| [17] |
Phillips SM. Nutritional supplements in support of resistance exercise to counter age-related sarcopenia[J]. Adv Nutr, 2015, 6(4):452-460.
doi: 10.3945/an.115.008367 |
| [18] |
Pierre N, Appriou Z, Gratas-Delamarche A, et al. From physical inactivity to immobilization: dissecting the role of oxidative stress in skeletal muscle insulin resistance and atrophy[J]. Free Radic Biol Med, 2016, 98:197-207.
doi: 10.1016/j.freeradbiomed.2015.12.028 |
| [19] |
Chen Z, Bozec A, Ramming A, et al. Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis[J]. Nat Rev Rheumatol, 2019, 15(1):9-17.
doi: 10.1038/s41584-018-0109-2 |
| [20] |
Nishikawa H, Fukunishi S, Asai A, et al. Pathophysiology and mechanisms of primary sarcopenia (review)[J]. Int J Mol Med, 2021, 48(2):156.
doi: 10.3892/ijmm.2021.4989 |
| [21] |
Zhou J, Liu B, Liang C, et al. Cytokine signaling in skeletal muscle wasting[J]. Trends Endocrinol Metab, 2016, 27(5):335-347.
doi: 10.1016/j.tem.2016.03.002 |
| [22] |
Zhao Q, Yang ST, Wang JJ, et al. TNF alpha inhibits myogenic differentiation of C2C12 cells through NF-κB activation and impairment of IGF-1 signaling pathway[J]. Biochem Biophys Res Commun, 2015, 458(4):790-795.
doi: 10.1016/j.bbrc.2015.02.026 |
| [23] |
Gonzalez-Freire M, Adelnia F, Moaddel R, et al. Searching for a mitochondrial root to the decline in muscle function with ageing[J]. J Cachexia Sarcopenia Muscle, 2018, 9(3):435-440.
doi: 10.1002/jcsm.12313 |
| [24] |
Bodine SC, Baehr LM. Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1[J]. Am J Physiol Endocrinol Metab, 2014, 307(6):E469-484.
doi: 10.1152/ajpendo.00204.2014 |
| [25] |
林苑, 陈进春. 类风湿关节炎患者营养状况的研究进展[J]. 风湿病与关节炎, 2022, 11(7):67-70.
doi: 10.3969/j.issn.2095-4174.2022.07.015 |
|
Lin Y, Chen JC. Research advances in nutritional status of patients with rheumatoid arthritis[J]. Rheumatism and Arthritis, 2022, 11(7):67-70.
doi: 10.3969/j.issn.2095-4174.2022.07.015 |
|
| [26] |
Hasegawa E, Kobayashi D, Kurosawa Y, et al. Nutritional status as the risk factor of serious infection in patients with rheumatoid arthritis[J]. Mod Rheumatol, 2020, 30(6):982-989.
doi: 10.1080/14397595.2019.1681653 |
| [27] | 龚勋, 徐胜前, 刘文, 等. 少肌症、维生素D缺乏在类风湿性关节炎合并脊柱骨质疏松性骨折中的临床研究[J]. 中国骨质疏松杂志, 2017, 23(2):221-226. |
| Gong X, Xu SQ, Liu W, et al. Clinical research of sarcopenia and vitamin D deficiency in patients with rheumatoid arthritis and spinal osteoporotic fractures[J]. Chin J Osteoporos, 2017, 23(2):221-226. | |
| [28] |
臧长海, 董海原. 风湿科住院患者的营养状况调查[J]. 中华内科杂志, 2010, 49(10):874-875.
doi: 10.3760/cma.j.issn.0578-1426.2010.10.017 |
|
Zang CH, Dong HY. Investigation of nutritional status in hospitalized rheumatology patients[J]. Chin J Intern Med, 2010, 49(10):874-875.
doi: 10.3760/cma.j.issn.0578-1426.2010.10.017 |
|
| [29] |
Jones G, Pilling LC, Kuo CL, et al. Sarcopenia and variation in the human leukocyte antigen complex[J]. J Gerontol A Biol Sci Med Sci, 2020, 75(2):301-308.
doi: 10.1093/gerona/glz042 |
| [30] |
何书励, 刘鹏举, 王勃诗, 等. 肌少症膳食指导与营养补充剂使用共识[J]. 实用老年医学, 2023, 37(6):649-652.
doi: 10.3969/j.issn.1003-9198.2023.06.028 |
|
He SL, Liu PJ, Wang BS, et al. Consensus on dietary guidance and the use of nutritional supplements for sarcopenia[J]. Pract Geriatr, 2023, 37(6):649-652.
doi: 10.3969/j.issn.1003-9198.2023.06.028 |
|
| [31] |
Ingegnoli F, Schioppo T, Scotti I, et al. Adherence to Mediterranean diet and patient perception of rheumatoid arthritis[J]. Complement Ther Med, 2020, 52:102519.
doi: 10.1016/j.ctim.2020.102519 |
| [32] |
Yokoyama Y, Kitamura A, Seino S, et al. Association of nutrient-derived dietary patterns with sarcopenia and its components in community-dwelling older Japanese: a cross-sectional study[J]. Nutr J, 2021, 20(1):7.
doi: 10.1186/s12937-021-00665-w |
| [33] |
Nazri NSM, Vanoh D, Soo KL. Natural food for sarcopenia: a narrative review[J]. Malays J Med Sci, 2022, 29(4):28-42.
doi: 10.21315/mjms2022.29.4.4 |
| [34] |
Toivanen P, Eerola E. A vegan diet changes the intestinal flora[J]. Rheumatology (Oxford), 2002, 41(8):950-951.
doi: 10.1093/rheumatology/41.8.950 |
| [35] |
Ganapathy A, Nieves JW. Nutrition and sarcopenia-what do we know?[J]. Nutrients, 2020, 12(6):1755.
doi: 10.3390/nu12061755 |
| [36] |
Rondanelli M, Nichetti M, Peroni G, et al. Where to find leucine in food and how to feed elderly with sarcopenia in order to counteract loss of muscle mass: practical advice[J]. Front Nutr, 2021, 7:622391.
doi: 10.3389/fnut.2020.622391 |
| [37] | Phillips SM, Martinson W. Nutrient-rich, high-quality, protein-containing dairy foods in combination with exercise in aging persons to mitigate sarcopenia[J]. Nutr Rev, 2019, 77(4):216-229. |
| [38] | Yoshimura Y, Wakabayashi H, Yamada M, et al. Interventions for treating sarcopenia:a systematic review and meta-analysis of randomized controlled studies[J]. J Am Med Dir Assoc, 2017, 18(6):553. |
| [39] |
Guo Y, Fu X, Hu Q, et al. The effect of leucine supplementation on sarcopenia-related measures in older adults: a systematic review and meta-analysis of 17 randomized controlled trials[J]. Front Nutr, 2022, 9:929891.
doi: 10.3389/fnut.2022.929891 |
| [40] |
Gilmartin S, O'Brien N, Giblin L. Whey for sarcopenia; can whey peptides, hydrolysates or proteins play a beneficial role?[J]. Foods, 2020, 9(6):750.
doi: 10.3390/foods9060750 |
| [41] | Thoma A, Lightfoot AP. NF-κB and inflammatory cytokine signalling: role in skeletal muscle atrophy[J]. Adv Exp Med Biol, 2018, 1088:267-279. |
| [42] | Sirbu E, Buleu F, Tudor A, et al. Vitamin D and disease activity in rheumatoid arthritis patients: a retrospective study in a Romanian cohort[J]. Acta Biochim Pol, 2020, 67(2):267-272. |
| [43] |
Park S, Ham JO, Lee BK. A positive association between stroke risk and sarcopenia in men aged ≥ 50 years, but not women: results from the Korean national health and nutrition examination survey 2008-2010[J]. J Nutr Health Aging, 2014, 18(9):806-812.
doi: 10.1007/s12603-014-0553-x |
| [44] |
Żebrowska A, Sadowska-Krępa E, Stanula A, et al. The effect of vitamin D supplementation on serum total 25(OH) levels and biochemical markers of skeletal muscles in runners[J]. J Int Soc Sports Nutr, 2020, 17(1):18.
doi: 10.1186/s12970-020-00347-8 |
| [45] |
Dawson-Hughes B, Wang J, Barger K, et al. Intra-trial mean 25(OH)D and PTH levels and risk of falling in older men and women in the Boston STOP IT trial[J]. J Clin Endocrinol Metab, 2022, 107(5):e1932-e1937.
doi: 10.1210/clinem/dgac012 |
| [46] |
Erbaba B, Arslan-Ergul A, Adams MM. Effects of caloric restriction on the antagonistic and integrative hallmarks of aging[J]. Ageing Res Rev, 2021, 66:101228.
doi: 10.1016/j.arr.2020.101228 |
| [47] |
Mizunoe Y, Kobayashi M, Saito H, et al. Prolonged caloric restriction ameliorates age-related atrophy in slow and fast muscle fibers of rat soleus muscle[J]. Exp Gerontol, 2021, 154:111519.
doi: 10.1016/j.exger.2021.111519 |
| [48] |
Dupont J, Dedeyne L, Dalle S, et al. The role of omega-3 in the prevention and treatment of sarcopenia[J]. Aging Clin Exp Res, 2019, 31(6):825-836.
doi: 10.1007/s40520-019-01146-1 |
| [49] | Abdulrazaq M, Innes JK, Calder PC. Effect of ω-3 polyunsaturated fatty acids on arthritic pain:a systematic review [J]. Nutrition, 2017, 39/40:57-66. |
| [50] |
Das A, Cumming RG, Naganathan V, et al. Associations between nutrient intakes and dietary patterns with different sarcopenia definitions in older Australian men: the concord health and ageing in men project - ERRATUM[J]. Public Health Nutr, 2021, 24(2):378-383.
doi: 10.1017/S1368980020004528 |
| [51] |
Grosicki GJ, Fielding RA, Lustgarten MS. Gut microbiota contribute to age-related changes in skeletal muscle size, composition, and function: biological basis for a gut-muscle axis[J]. Calcif Tissue Int, 2018, 102(4):433-442.
doi: 10.1007/s00223-017-0345-5 |
| [52] | Alwarith J, Kahleova H, Rembert E, et al. Nutrition interventions in rheumatoid arthritis:the potential use of plant-based diets[J]. Front Nutr, 2019, 6:141. |
| [53] |
Robinson SM, Reginster JY, Rizzoli R, et al. Does nutrition play a role in the prevention and management of sarcopenia?[J]. Clin Nutr, 2018, 37(4):1121-1132.
doi: 10.1016/j.clnu.2017.08.016 |
| [54] | Jalili M, Kolahi S, Aref-Hosseini SR, et al. Beneficial role of antioxidants on clinical outcomes and erythrocyte antioxidant parameters in rheumatoid arthritis patients[J]. Int J Prev Med, 2014, 5(7):835-840. |
| [55] | var Dronkelaar C, van Velzen A, Abdelrazek M, et al. Minerals and sarcopenia; the role of calcium, iron, magnesium, phosphorus, potassium, selenium, sodium, and zinc on muscle mass, muscle strength, and physical performance in older adults:a systematic review[J]. J Am Med Dir Assoc, 2018, 19(1):6-11. e3. |
| [56] | Miggiano GA, Gagliardi L. Diet, nutrition and rheumatoid arthritis[J]. Clin Ter, 2005, 156(3):115-123. |
| [57] |
Neville CE, Young IS, Gilchrist SE, et al. Effect of increased fruit and vegetable consumption on physical function and muscle strength in older adults[J]. Age (Dordr), 2013, 35(6):2409-2422.
doi: 10.1007/s11357-013-9530-2 |
| [58] |
Swart KM, Ham AC, van Wijngaarden JP, et al. A randomized controlled trial to examine the effect of 2-year vitamin B12 and folic acid supplementation on physical performance, strength, and falling: additional findings from the B-PROOF study[J]. Calcif Tissue Int, 2016, 98(1):18-27.
doi: 10.1007/s00223-015-0059-5 |
| [59] |
Besora-Moreno M, Llauradó E, Valls RM, et al. Antioxidant-rich foods, antioxidant supplements, and sarcopenia in old-young adults ≥55 years old: a systematic review and meta-analysis of observational studies and randomized controlled trials[J]. Clin Nutr, 2022, 41(10):2308-2324.
doi: 10.1016/j.clnu.2022.07.035 |
| [60] |
王奕杰, 张圣群, 黄添隆. 天然抗氧化物在肌少症疾病中应用的研究现状[J]. 中国临床药理学杂志, 2023, 39(10):1505-1510.
doi: 10.13699/j.cnki.1001-6821.2023.10.029 |
|
Wang YJ, Zhang SQ, Huang TL. Application of natural antioxidants in the study of sarcopenia[J]. Chin J Clin Pharmacol, 2023, 39(10):1505-1510.
doi: 10.13699/j.cnki.1001-6821.2023.10.029 |
| [1] | 张音, 沈宏华, 许轶明, 杜井波, 刘杰, 吴顺军, 凌小楠, 任蕾. 运动联合营养干预对老年肌少症体成分和躯体功能及睡眠质量的影响[J]. 内科理论与实践, 2026, 21(01): 28-38. |
| [2] | 王怡, 黄辉. 慢性阻塞性肺疾病合并肌少症的研究新进展[J]. 内科理论与实践, 2025, 20(05): 415-419. |
| [3] | 杨启瑞, 白婷婷, 蒋倩雯, 张伟奇, 鲁怡音, 赵伟, 吴方, 李菲卡. 老年射血分数保留型心力衰竭患者合并肌少症预后因素分析[J]. 内科理论与实践, 2025, 20(03): 210-215. |
| [4] | 武梦梦, 杨福燕, 刘雨辰, 鲁旭柯, 高静歌, 叶紫灵. 维持性血液透析的2型糖尿病肾病患者并发肌少症的相关因素分析[J]. 内科理论与实践, 2024, 19(02): 102-106. |
| [5] | 黄怡, 杨梦, 刘航序. 肌少症与老年肺炎的发生及预防策略[J]. 内科理论与实践, 2024, 19(01): 1-5. |
| [6] | 郦源, 张乐, 殷翰林, 郑冰, 吕良敬. 抗核抗体在类风湿关节炎中的临床研究进展[J]. 诊断学理论与实践, 2023, 22(06): 579-586. |
| [7] | 赵雅洁, 何清, 徐志红. 肌少症对老年慢性阻塞性肺疾病患者生活质量及活动能力的影响[J]. 内科理论与实践, 2023, 18(06): 383-387. |
| [8] | 李笑石, 秦越. 影像学技术在痛风诊断及疾病监测中的应用研究进展[J]. 诊断学理论与实践, 2023, 22(03): 311-318. |
| [9] | 张音, 沈宏华, 许轶明, 任蕾, 李骏, 吴顺军, 凌小楠. 肌少症合并腹型肥胖对住院老年人肌力及躯体功能的影响[J]. 内科理论与实践, 2023, 18(02): 76-82. |
| [10] | 施咏梅, 蒋咏梅, 罗茜, 金倩雯, 陈尔真. 瑞金医院新型冠状病毒感染病人营养治疗建议(2023版)[J]. 外科理论与实践, 2023, 28(01): 49-52. |
| [11] | 李菲卡, 杨文丽, 蒋倩雯, 方芳, 白婷婷, 徐刚, 吴方, 何清. 基于德尔菲专家咨询法构建的老年肌少症评估初始量表[J]. 内科理论与实践, 2022, 17(03): 238-242. |
| [12] | 王宏智, 袁昳玮. 类风湿关节炎的慢病管理[J]. 内科理论与实践, 2022, 17(03): 202-207. |
| [13] | 宣呈杰, 卞冬生, 蒋咏梅, 陈宇菲, 金佳斌, 施咏梅. 营养治疗对减重术后身体成分及静息能量消耗的影响[J]. 外科理论与实践, 2022, 27(03): 244-248. |
| [14] | 高磊, 高艳虹. 肌少症与抑郁症之间关系的研究进展[J]. 内科理论与实践, 2021, 16(06): 442-446. |
| [15] | 张音, 沈宏华, 许轶明, 任蕾. 肌少症的诊断与治疗研究进展[J]. 内科理论与实践, 2021, 16(03): 220-224. |
| 阅读次数 | ||||||
|
全文 |
|
|||||
|
摘要 |
|
|||||