继发性急性髓系白血病发病机制与临床特征研究进展

doi:10.16138/j.1673-6087.2026.02.16

摘要/Abstract

摘要：

继发性急性髓系白血病（secondary acute myeloid leukemia，sAML）是指急性髓系白血病（acute myeloid leukemia，AML）发生在原有血液系统疾病基础上，或既往实体瘤患者经化疗或放疗后发生的疾病。相较于原发性AML，该类疾病发病率较低，但发病机制复杂，患者总生存期更短，因此深入研究sAML的发病机制与临床特征具有重要的临床意义。

关键词: 继发性急性髓系白血病, 临床特征, 治疗, 预后

Abstract:

Secondary acute myeloid leukemia (sAML) refers to AML that occurs on the basis of a pre-existing hematological disease, or in patients with previous solid tumors who have undergone chemotherapy or radiotherapy. Compared with primary AML, the incidence of this type of disease is lower, but its pathogenesis is complex, and the overall survival of patients is shorter. Therefore, in-depth research on the pathogenesis and clinical features of sAML has important clinical significance.

Key words: secondary acute myeloid leukemia, clinical features, treatment, prognosis

高铭敏, 吴涛, 刘文慧. 继发性急性髓系白血病发病机制与临床特征研究进展[J]. 内科理论与实践, 2026, 21(02): 199-204.

GAO Mingmin, WU Tao, LIU Wenhui. Research progress on the pathogenesis and clinical features of secondary acute myeloid leukemia[J]. Journal of Internal Medicine Concepts & Practice, 2026, 21(02): 199-204.

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