系统性红斑狼疮相关脑损伤的神经影像学研究进展

doi:10.16138/j.1673-6087.2026.03.17

内科理论与实践 ›› 2026, Vol. 21 ›› Issue (03): 289-295.doi: 10.16138/j.1673-6087.2026.03.17

系统性红斑狼疮相关脑损伤的神经影像学研究进展

沈枫¹^,²^,^*(), 张国芳¹^,^*, 杨一帆¹, 白茹¹, 李姝¹, 刘爽¹, 程宇琪³, 徐健¹()

1.昆明医科大学第一附属医院风湿免疫科，云南昆明　650032
2.开远市人民医院重症医学科，云南红河　661699
3.浙江大学医学院附属精神卫生中心心身科，浙江杭州　310063

收稿日期:2025-05-20 修回日期:2025-08-27 接受日期:2025-09-04 出版日期:2026-06-25 发布日期:2026-08-19
通讯作者: 徐健 E-mail：casxujian@163.com
作者简介:*沈枫与张国芳为共同第一作者
作者贡献/Authors’ Contributions沈枫、张国芳负责文献收集、论文撰写；杨一帆负责论文审核、论文修改；白茹负责功能磁共振部分文献收集、论文审核；李姝负责结构磁共振部分文献收集、论文审核；刘爽负责fNIRS部分文献收集、论文审核；程宇琪负责论文审核、撰写指导；徐健负责整体撰写指导、研究经费支持。
基金资助:
国家自然科学基金项目(32270947);云南省卫生健康委员会医学领军人才培养计划(L-2019004);云南省“万人计划”专项培养计划(YNWR-MY-2018-040);云南省临床医学中心科研项目(YWLCYXZX2023300076);云南省临床医学中心科研项目(2024YNLCYXZX0019);云南省科技计划项目(2018ZF016)

Research progress in neuroimaging of systemic lupus erythematosus-related brain injury

SHEN Feng¹^,²^,^*(), ZHANG Guofang¹^,^*, YANG Yifan¹, BAI Ru¹, LI Shu¹, LIU Shuang¹, CHENG Yuqi³, XU Jian¹()

1. Department of Rheumatology and Immunology, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, China
2. Department of Critical Care Medicine, Kaiyuan People's Hospital, Honghe 661699, China
3. Department of Psychosomatic Medicine, Mental Health Center, Zhejiang University School of Medicine, Hangzhou 310063, China

Received:2025-05-20 Revised:2025-08-27 Accepted:2025-09-04 Online:2026-06-25 Published:2026-08-19

摘要/Abstract

摘要：

神经影像学的快速进展为观察系统性红斑狼疮（systemic lupus erythematosus, SLE）相关脑损伤功能异常及探索其潜在机制提供了重要工具。本文从“结构-功能”整合视角综述神经影像学技术在SLE中的研究进展，旨在归纳SLE脑损伤的现有研究思路，为其多模态影像研究及临床转化提供参考。

关键词: 神经影像学, 脑结构, 脑功能, 系统性红斑狼疮

Abstract:

The rapid advancements of neuroimaging have provided support for characterizing structural and functional brain abnormalities associated with systemic lupus erythematosus (SLE). This article reviews the research progress of neuroimaging techniques in SLE from a “structure-function” integration perspective, aiming to consolidate the existing research approaches to SLE-related brain injury and to promote the development of multimodal research integrating clinical characteristics, brain structure and brain function.

Key words: neuroimaging, brain structure, brain function, systemic lupus erythematosus

中图分类号:

R593.24

沈枫, 张国芳, 杨一帆, 白茹, 李姝, 刘爽, 程宇琪, 徐健. 系统性红斑狼疮相关脑损伤的神经影像学研究进展[J]. 内科理论与实践, 2026, 21(03): 289-295.

SHEN Feng, ZHANG Guofang, YANG Yifan, BAI Ru, LI Shu, LIU Shuang, CHENG Yuqi, XU Jian. Research progress in neuroimaging of systemic lupus erythematosus-related brain injury[J]. Journal of Internal Medicine Concepts & Practice, 2026, 21(03): 289-295.

图/表 2

参考文献 44

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系统性红斑狼疮相关脑损伤的神经影像学研究进展

Research progress in neuroimaging of systemic lupus erythematosus-related brain injury

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