综述

早发2型糖尿病流行病学、临床特征及病因机制的研究进展

展开
  • 1.上海交通大学医学院附属新华医院老年医学科,上海 200092
    2.上海交通大学附属第一人民医院老年医学科,上海 200080

收稿日期: 2021-11-25

  网络出版日期: 2022-08-08

基金资助

上海市科学技术委员会科研计划项目(18411964500)

本文引用格式

高晶晶, 高艳虹 . 早发2型糖尿病流行病学、临床特征及病因机制的研究进展[J]. 内科理论与实践, 2022 , 17(04) : 344 -348 . DOI: 10.16138/j.1673-6087.2022.04.015

参考文献

[1] Cho NH, Shaw JE, Karuranga S, et al. IDF diabetes atlas: global estimates of diabetes prevalence for 2017 and projections for 2045[J]. Diabetes Res Clin Pract, 2018, 138: 271-281.
[2] Zheng Y, Ley SH, Hu FB. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications[J]. Nat Rev Endocrinol, 2018, 14(2): 88-98.
[3] Viner R, White B, Christie D. Type 2 diabetes in adolescents: a severe phenotype posing major clinical challenges and public health burden[J]. Lancet, 2017, 389(10085): 2252-2260.
[4] International Diabetes Federation. IDF Diabetes Atlas[J]. 2017: 147.
[5] Sun H, Saeedi P, Karuranga S, et al. IDF Diabetes Atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045[J]. Diabetes Res Clin Pract, 2022, 183: 109119.
[6] Zhang Y, Ning G. Diabetes: young-onset type 2 diabetes mellitus-a challenge for Asia[J]. Nat Rev Endocrinol, 2014, 10(12): 703-704.
[7] Wang L, Gao P, Zhang M, et al. Prevalence and ethnic pattern of diabetes and prediabetes in China in 2013[J]. JAMA, 2017, 317(24): 2515-2523.
[8] Ogurtsova K, da Rocha Fernandes JD, Huang Y, et al. IDF diabetes atlas: global estimates for the prevalence of diabetes for 2015 and 2040[J]. Diabetes Res Clin Pract, 2017, 128: 40-50.
[9] Candler TP, Mahmoud O, Lynn RM, et al. Continuing rise of type 2 diabetes incidence in children and young people in the UK[J]. Diabet Med, 2018, 35(6): 737-744.
[10] 刘杰, 顾天伟, 钟胜利, 等. 住院早发2型糖尿病患者代谢特征及慢性并发症情况[J]. 中华糖尿病杂志, 2020, 12(6): 387-392.
[11] Wilmot E, Idris I. Early onset type 2 diabetes: risk factors, clinical impact and management[J]. Ther Adv Chr-onic Dis, 2014, 5(6): 234-244.
[12] Barrett T, Jalaludin MY, Turan S, et al. Rapid progression of type 2 diabetes and related complications in children and young people — a literature review[J]. Pediatr Diabetes, 2020, 21(2): 158-172.
[13] Yeung RO, Zhang Y, Luk A, et al. Metabolic profiles and treatment gaps in young-onset type 2 diabetes in Asia (the JADE programme)[J]. Lancet Diabetes Endocrinol, 2014, 2(12): 935-943.
[14] Nanayakkara N, Curtis AJ, Heritier S, et al. Impact of age at type 2 diabetes mellitus diagnosis on mortality and vascular complications: systematic review and meta-analyses[J]. Diabetologia, 2021, 64(2): 275-287.
[15] Wu Y, Wang Y, Zhang J, et al. Early-onset of type 2 diabetes mellitus is a risk factor for diabetic nephropathy progression: a biopsy-based study[J]. Aging (Albany NY), 2021, 13(6): 8146-8154.
[16] Hui Y, Wang J, An Y, et al. Premature death and risk of cardiovascular disease in young-onset diabetes: a 23-year follow-up of the Da Qing Diabetes Study[J]. Endocrine, 2019, 65(1): 46-52.
[17] Huo L, Magliano DJ, Rancière F, et al. Impact of age at diagnosis and duration of type 2 diabetes on mortality in Australia 1997-2011[J]. Diabetologia, 2018, 61(5): 1055-1063.
[18] Lascar N, Brown J, Pattison H, et al. Type 2 diabetes in adolescents and young adults[J]. Lancet Diabetes Endocrinol, 2018, 6(1): 69-80.
[19] 吕欣璐, 陈香均, 汪志红. 早发2型糖尿病:流行病学,危险因素及其与并发症的研究现状[J]. 世界最新医学信息文摘, 2020, 20(27): 94-95.
[20] Magliano DJ, Sacre JW, Harding JL, et al. Young-onset type 2 diabetes mellitus - implications for morbidity and mortality[J]. Nat Rev Endocrinol, 2020, 16(6): 321-331.
[21] Zhou S, Meng X, Wang S, et al. A 3-year follow-up study of β-cell function in patients with early-onset type 2 diabetes[J]. Exp Ther Med, 2016, 12(2): 1097-1102.
[22] Zou X, Zhou X, Ji L, et al. The characteristics of newly diagnosed adult early-onset diabetes: a population-based cross-sectional study[J]. Sci Rep, 2017, 7: 46534.
[23] Mohan V, Amutha A, Ranjani H, et al. Associations of β-cell function and insulin resistance with youth-onset type 2 diabetes and prediabetes among Asian Indians[J]. Diabetes Technol Ther, 2013, 15(4): 315-322.
[24] Bacha F, Pyle L, Nadeau K, et al. Determinants of glycemic control in youth with type 2 diabetes at randomization in the TODAY study[J]. Pediatr Diabetes, 2012, 13(5): 376-383.
[25] TODAY Study Group. Effects of metformin, metformin plus rosiglitazone, and metformin plus lifestyle on insulin sensitivity and β-cell function in TODAY[J]. Diabetes Care, 2013, 36(6): 1749-1757.
[26] TODAY Study Group. Postintervention effects of varying treatment arms on glycemic failure and β-cell function in the today trial[J]. Diabetes Care, 2021, 44(1): 75-80.
[27] Šrámek J, Němcová-Fürstová V, Kovář. Molecular mechanisms of apoptosis induction and its regulation by fatty acids in pancreatic β-cells[J]. Int J Mol Sci, 2021, 22(8):4285.
[28] Ding Y, Yang GY, Wu Q. Autophagic dysfunction of β cell dysfunction in type 2 diabetes, a double-edged sword[J]. Genes Dis, 2020, 8(4): 438-447.
[29] Bensellam M, Jonas JC, Laybutt DR. Mechanisms of β-cell dedifferentiation in diabetes: recent findings and future research directions[J]. J Endocrinol, 2018, 236(2): R109-R143.
[30] Lee EY, Yoon KH. Epidemic obesity in children and adolescents: risk factors and prevention[J]. Front Med, 2018, 12(6): 658-666.
[31] Twig G, Zucker I, Afek A, et al. Adolescent obesity and early-onset type 2 diabetes[J]. Diabetes Care, 2020, 43(7): 1487-1495.
[32] Ahmed B, Sultana R, Greene MW. Adipose tissue and insulin resistance in obese[J]. Biomed Pharmacother, 2021, 137: 111315.
[33] Tagi VM, Chiarelli F. Obesity and insulin resistance in children[J]. Curr Opin Pediatr, 2020, 32(4): 582-588.
[34] 曹晶珠, 王元辰, 洪惠兰, 等. 不同体质指数早发2型糖尿病的临床特征分析[J]. 中国临床医学, 2019, 26(1): 14-18.
[35] Hao Z, Huang X, Liu X, et al. Association analysis between different diabetic family history and gender with diagnosed age of type 2 diabetes mellitus: a cross-sectional study in Tianjin, China[J]. Inquiry, 2022, 59: 4695 80221086364.
[36] Piko P, Werissa NA, Fiatal S, et al. Impact of genetic factors on the age of onset for type 2 diabetes mellitus in addition to the conventional risk aactors[J]. J Pers Med, 2020, 11(1): 6.
[37] Kong X, Xing X, Zhang X, et al. Early-onset type 2 diabetes is associated with genetic variants of β-cell function in the Chinese Han population[J]. Diabetes Metab Res Rev, 2020, 36(2): e3214.
[38] Norris SA, Daar A, Balasubramanian D, et al. Understanding and acting on the developmental origins of health and disease in Africa would improve health across generations[J]. Glob Health Action, 2017, 10(1): 1334985.
[39] Tam CHT, Ma RCW, Yuen LY, et al. The impact of maternal gestational weight gain on cardiometabolic risk factors in children[J]. Diabetologia, 2018, 61(12): 2539-2548.
[40] Kadayifci FZ, Haggard S, Jeon S, et al. Early-life programming of type 2 diabetes mellitus: understanding the association between epigenetics/genetics and environmental factors[J]. Curr Genomics, 2019, 20(6): 453-463.
[41] 周丽媛, 肖新华. 生命早期营养与糖代谢异常发生发展的新启示:糖尿病防治窗口需前移[J]. 中华糖尿病杂志, 2021, 13(12): 1109-1114.
[42] Isganaitis EM, Shah R, Chernausek S, et al. 19-Or: maternal diabetes is associated with adverse diabetes characteristics and accelerated onset of complications in youth with type 2 diabetes (t2d) in today[J]. 2021, 70 Suppl 1: 19-OR.
[43] 牛海芳. 早发2型糖尿病患者发病的危险因素及其在不同性别间的差异[J]. 广西医学, 2020, 42(14): 1804-1807.
[44] Park JI, Baek H, Kim SW, et al. Questionnaire-based survey of demographic and clinical characteristics, health behaviors, and mental health of young Korean adults with early-onset diabetes[J]. J Korean Med Sci, 2021, 36(26): e182.
[45] Fiore V, Marci M, Poggi A, et al. The association between diabetes and depression: a very disabling condition[J]. Endocrine, 2015, 48(1): 14-24.
[46] Li FF, Liu BL, Yin GP, et al. Young onset type 2 diabetic patients might be more sensitive to metformin compared to late onset type 2 diabetic patients[J]. Sci Rep, 2017, 7(1): 16382.
[47] Matthews DR, Paldánius PM, Proot P, et al. Glycaemic durability of an early combination therapy with vildagliptin and metformin versus sequential metformin monotherapy in newly diagnosed type 2 diabetes (VERIFY): a 5-year, multicentre, randomised, double-blind trial[J]. Lancet, 2019, 394(10208): 1519-1529.
[48] Pan J, Jia W. Early-onset diabetes: an epidemic in China[J]. Front Med, 2018, 12(6): 624-633.
文章导航

/