内科理论与实践

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2024 , Vol. 19 >Issue 02: 130 - 135

DOI: https://doi.org/10.16138/j.1673-6087.2024.02.08

综述

肠道菌群介导阻塞性睡眠呼吸暂停患者代谢及心血管异常的作用及相关机制进展

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  • 1.南京医科大学附属无锡人民医院内分泌科，江苏 无锡 214023
    2.江南大学食品学院，江苏 无锡 214023
吴文君 E-mail：wuwenjung@163.com

收稿日期: 2023-08-10

  网络出版日期: 2024-07-08

基金资助

国家自然科学基金项目(32172212);无锡市“双百”中青年医疗卫生拔尖人才培养项目(BJ2020005);无锡市科技发展资金项目(Y20212024);南京医科大学无锡医学中心专病队列和临床研究项目(WMCC202322)

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Role of gut microbiota in mediating metabolic and cardiovascular abnormalities in patients with obstructive sleep apnea and related mechanisms

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  • 1. Department of Endocrinology, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi 214023, China
    2. School of Food Science and Technology, Jiangnan University, Wuxi 214023, China

Received date: 2023-08-10

  Online published: 2024-07-08

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摘要

阻塞性睡眠呼吸暂停（obstructive sleep apnea，OSA）是一种常见的以间歇性缺氧和睡眠片段化为主要病理特征的睡眠障碍性疾病，与高血压、动脉粥样硬化、胰岛素抵抗等多种代谢疾病的发生、发展关系密切。大量研究已发现OSA会引起肠道菌群紊乱从而对人体健康产生影响。本文就临床与动物模型中OSA引起肠道菌群紊乱以及相关代谢和心血管变化的可能机制以及由此衍生的辅助治疗新方法进行综述，旨在以肠道菌群为切入点，重新认识OSA和代谢及心血管异常之间的关系，为OSA及相关并发症的早期干预提供新思路。

关键词： 阻塞性睡眠呼吸暂停; 肠道菌群; 高血压; 动脉粥样硬化; 糖尿病

本文引用格式

朱晓雯, 王鸿超, 吴文君 . 肠道菌群介导阻塞性睡眠呼吸暂停患者代谢及心血管异常的作用及相关机制进展[J]. 内科理论与实践, 2024 , 19(02) : 130 -135 . DOI: 10.16138/j.1673-6087.2024.02.08

Abstract

Obstructive sleep apnea (OSA) is a common sleep disorder characterized by intermittent hypoxia and sleep fragmentation, which is closely associated with the development of hypertension, atherosclerosis, insulin resistance and other metabolic diseases. A lot of studies have found that OSA can cause the disturbance of gut microbiota and affect human health. This paper reviews the possible mechanisms of gut microbiota disturbance and related metabolic and cardiovascular changes caused by OSA in clinical trials and animal models, and the new complementary therapies derived from them. The aim of the paper is to use gut microbiota as an entry point to re-understand the relationship between OSA and metabolic and cardiovascular abnormalities, and provides new ideas for early intervention of OSA and related complications.

Key words： Obstructive sleep apnea; Gut microbiota; Hypertension; Atherosclerosis; Diabetes mellitus

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