内科理论与实践

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2025 , Vol. 20 >Issue 04: 312 - 315

DOI: https://doi.org/10.16138/j.1673-6087.2025.04.09

研究报道

改良开放式创口唇腺活检术在干燥综合征患者临床应用相关研究

  • 陈亚冰 ,
  • 高洁 ,
  • 徐霞 ,
  • 赵东宝
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  • 海军军医大学第一附属医院风湿免疫科，上海 200433
赵东宝 E-mail: dongbaozhao@163.com

收稿日期: 2024-11-14

  网络出版日期: 2025-10-27

基金资助

海军军医大学第一附属“长风”人才培养计划

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Clinical evaluation of the modified open wound sutureless labial gland biopsy technique for patient with Sjögren syndrome

  • CHEN Yabing ,
  • GAO Jie ,
  • XU Xia ,
  • ZHAO Dongbao
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  • Department of Rheumatology and Immunology, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, China

Received date: 2024-11-14

  Online published: 2025-10-27

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摘要

目的：探讨改良开放式创口唇腺活检术（sutureless labial gland biopsy, SLSGB）应用于干燥综合征患者诊断的临床价值。方法：将2023年3月至2025年4月在我科进行唇腺活检术的24例患者分为SLSGB组和传统口腔唇腺活检术（traditional labial salivary gland biopsy, TLSGB）组。采用0~10级疼痛数字评分法（numerical rating scale，NRS）对2组患者术后恢复时间、术后2 h、术后第1天和术后第7天切口疼痛进行评估. 结果: 术后恢复时间评分，TLSGB组为（6.67±0.82）分，SLSGB组为（2.00±0.00）分，2组差异有统计学意义（P<0.001）；NRS评分术后2 h、术后第1天、术后第7天TLSGB组分别为（5.83±0.98）、（2.67±0.52）、（2.00±0.63）分，SLSGB组分别为（1.72±0.46）、0、0分，术后2 h和术后第1天2组差异有统计学意义（均P<0.05），术后第7天2组差异无统计学意义（P>0.05）。结论：SLSGB不仅创伤小，不易造成二次损伤，无需拆线，操作简便，且很少出现并发症，可显著降低患者的经济与时间成本，患者接受度高。

关键词： 干燥综合征; 开放式创口唇腺活检; 术后恢复

本文引用格式

陈亚冰 , 高洁 , 徐霞 , 赵东宝 . 改良开放式创口唇腺活检术在干燥综合征患者临床应用相关研究[J]. 内科理论与实践, 2025 , 20(04) : 312 -315 . DOI: 10.16138/j.1673-6087.2025.04.09

Abstract

Objective To explore the clinical value of modified open-wound sutureless labial gland biopsy for patients with Sjögren syndrome. Methods A total of 24 patients who underwent labial gland biopsy in our department from March 2023 to April 2025 were divided into the sutureless labial gland biopsy (SLSGB) group and the traditional labial salivary gland biopsy (TLSGB) group. The numerical rating scale (NRS) 0-10 was used to evaluate the postoperative recovery time and incision pain at 2 h, 1 d, and 7 d after surgery in both groups. Results The postoperative recovery time score was (6.67±0.82) points in the TLSGB group and (2.00±0.00) points in the SLSGB group (P< 0.001). The NRS scores at 2 h, 1 d, and 7 d after surgery were (5.83±0.98), (2.67±0.52), and (2.00±0.63) points in the TLSGB group, and (1.72±0.46), 0, and 0 points in the SLSGB group, respectively. There were significant differences between the two groups at 2 h and 1 d after surgery (both P<0.05), but there was no statistical difference at 7 d after surgery (P>0.05). Conclusions Open incision labial gland biopsy is less invasive, less prone to secondary injury, does not require suture removal, is easy to operate, and rarely causes complications. It can reduce significantly the economic and time costs and it’s more easily accepted by patients.

Key words： Sjögren syndrome; Sutureless labial gland biopsy; Postoperative recovery

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