未经免疫治疗症状好转的抗二肽基肽酶样蛋白 6脑炎1例
收稿日期: 2025-07-21
录用日期: 2025-12-05
网络出版日期: 2025-12-26
版权
Anti-dipeptidyl-peptidase-like protein 6 encephalitis with symptom improvement without immunotherapy：a case report
Received date: 2025-07-21
Accepted date: 2025-12-05
Online published: 2025-12-26
Copyright
抗二肽基肽酶样蛋白6（dipeptidyl-peptidase-like protein 6, DPPX）抗体相关脑炎是一种罕见的自身免疫性脑炎。本病例为1例急性起病的老年男性，主要症状为言语含糊、肢体麻木、头晕及行走不稳，有明确的前驱感染病史，血清和脑脊液中抗DPPX抗体均呈阳性，且合并血清中抗神经节苷脂GQ1b（ganglioside GQ1b, GQ1b）抗体阳性，头颅磁共振成像未见明显急性脑血管病、肿瘤等相关病灶，全身其余脏器及淋巴结筛查未发现相关肿瘤，未经免疫治疗，患者症状逐渐好转。本病例丰富了抗DPPX抗体相关脑炎的临床、诊断及预后资料。
关键词： 脑炎; 抗二肽基肽酶样蛋白6抗体; 临床特征
李雪莹 , 刘晓红 , 赵薇 . 未经免疫治疗症状好转的抗二肽基肽酶样蛋白 6脑炎1例[J]. 内科理论与实践, 2025 , 20(05) : 381 -384 . DOI: 10.16138/j.1673-6087.2025.05.06
Anti-dipeptidyl-peptidase-like protein 6 (DPPX) antibody-associated encephalitis is a rare autoimmune encephalitis. This case report describes an elderly male patient with acute onset, whose main symptoms included slurred speech, limb numbness, dizziness, and unsteady gait. The patient had a clear history of preceding infection. Anti-DPPX antibodies were positive in both serum and cerebrospinal fluid, with concurrent seropositivity for anti-ganglioside GQ1b (GQ1b) antibodies. Brain magnetic resonance imaging showed no evidence of acute cerebrovascular disease, tumors, or related lesions. Screening of other systemic organs and lymph nodes revealed no associated malignancies. Without immunotherapy, the patient’s symptoms gradually improved. This case enriches the clinical, diagnostic, and prognostic data on anti-DPPX antibody-associated encephalitis.
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