获得性免疫缺陷综合征患者免疫重建不良研究进展
收稿日期: 2026-01-21
修回日期: 2026-02-13
录用日期: 2026-02-25
网络出版日期: 2026-04-08
版权
Research progress on immunological non-response in acquired immunodeficiency syndrome patients
Received date: 2026-01-21
Revised date: 2026-02-13
Accepted date: 2026-02-25
Online published: 2026-04-08
Copyright
尽管高效抗逆转录病毒治疗（highly active antiretroviral therapy, HAART）可实现长期稳定的病毒学抑制，仍有部分获得性免疫缺陷综合征患者治疗后CD4+T细胞计数恢复不佳，通常称为免疫无应答（immune non-response, INR）或免疫重建不良。目前，INR缺乏统一的国际定义和判定阈值，不同研究报道的发病率差异显著。INR与多种因素相关，但关键机制尚未明确，临床上亦缺乏有效的治疗方案。本文系统梳理获得性免疫缺陷综合征相关研究中INR的定义、影响因素及治疗措施，旨在为后续研究提供参考，并为开发针对INR的有效治疗策略奠定基础。
关键词： 人类免疫缺陷病毒; 获得性免疫缺陷综合征; 免疫无应答; 高效抗逆转录病毒治疗; CD4+T细胞; 流行病学
齐青松 , 田美娜 , 于瑶 . 获得性免疫缺陷综合征患者免疫重建不良研究进展[J]. 内科理论与实践, 2026 , 21(01) : 3 -11 . DOI: 10.16138/j.1673-6087.2026.01.01
Although highly active antiretroviral therapy (HAART) can achieve long-term and stable viral suppression, some patients with acquired immunodeficiency syndrome still exhibit poor recovery of CD4+ T cell counts after treatment. This condition is commonly referred to as immune non-response (INR). Currently, there is no unified international definition or diagnostic threshold for INR, and the incidence rates reported in different studies vary significantly. INR is associated with multiple factors, but its key mechanisms remain unclear, and effective clinical treatment strategies are still lacking. This article systematically reviews the definitions, influencing factors, and therapeutic approaches for INR in acquired immunodeficiency syndrome-related research, aiming to provide a reference for subsequent studies and lay a foundation for the development of effective treatment strategies for INR.
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