获得性免疫缺陷综合征相关卡波西肉瘤多器官受累特征与诊疗策略
收稿日期: 2026-01-19
修回日期: 2026-02-05
录用日期: 2026-02-06
网络出版日期: 2026-04-08
基金资助
四川省临床重点专科建设项目(2023AGRKP001)
版权
Features of multi-organ involvement and management strategies in AIDS-related Kaposi sarcoma
Received date: 2026-01-19
Revised date: 2026-02-05
Accepted date: 2026-02-06
Online published: 2026-04-08
Copyright
卡波西肉瘤（Kaposi sarcoma，KS）是一种与免疫抑制、KS相关疱疹病毒（Kaposi sarcoma-associated herpesvirus，KSHV）感染密切相关的多中心性肿瘤，KSHV感染与人类免疫缺陷病毒（human immunodeficiency virus，HIV）感染的协同作用共同导致获得性免疫缺陷综合征（acquired immunodeficiency syndrome, AIDS）相关KS（AIDS-KS）的发生发展。AIDS-KS是AIDS患者中最常见的恶性肿瘤之一，需引起临床高度重视。本文系统阐述了AIDS-KS的多中心发病机制、不同器官受累的特异性临床表现和分层诊疗策略，重点强调了抗逆转录病毒治疗（antiretroviral therapy，ART）联合肿瘤靶向治疗在疾病管理中的重要性。通过实施个体化及多学科综合管理策略，更好地控制疾病进展，提高患者生存质量及预后。
张亚萍 , 王力 , 何沅鸿 , 尹科 , 杨彤彤 . 获得性免疫缺陷综合征相关卡波西肉瘤多器官受累特征与诊疗策略[J]. 内科理论与实践, 2026 , 21(01) : 68 -73 . DOI: 10.16138/j.1673-6087.2026.01.10
Kaposi sarcoma (KS) is a multicentric tumor closely associated with immunosuppression and KS-associated herpesvirus (KSHV) infection. The synergistic interaction between KSHV infection and human immunodeficiency virus (HIV) infection promotes the occurrence and progression of acquired immunodeficiency syndrome (AIDS)-associated KS (AIDS-KS). AIDS-KS is one of the most common malignancies in AIDS patients and thus requires high clinical attention. This article systematically reviews the multicentric pathogenesis of AIDS-KS, the specific clinical manifestations of involvement in different organs and stratified diagnostic and therapeutic strategies, with particular emphasis on the importance of combining antiretroviral therapy (ART) and targeted therapy in disease management. The implementation of individualized and multidisciplinary comprehensive management strategies can better control disease progression and improve patients’ quality of life as well as prognosis.
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