内科理论与实践

内科理论与实践 >

2026 , Vol. 21 >Issue 01: 74 - 79

DOI: https://doi.org/10.16138/j.1673-6087.2026.01.11

综述

衰老异质性的研究进展

  • 王廷旭 ,
  • 王旭 ,
  • 周廉尧 ,
  • 尹硕 ,
  • 代敬宇 ,
  • 叶静
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  • 1.上海交通大学医学院，上海 200025
    2.上海交通大学生物医学工程学院，上海 200241
    3.上海交通大学医学院附属瑞金医院老年科，上海 200025
*：王廷旭和王旭为共同第一作者
叶 静 E-mail：yj11254@rjh.com.cn

收稿日期: 2024-11-12

  网络出版日期: 2026-04-08

基金资助

上海交通大学医学院大学生创新训练计划(1723Y091)

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《内科理论与实践》编辑部, 2025, 版权所有，未经授权，不得转载、摘编本刊文章，不得使用本刊的版式设计。
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Research progress on heterogeneity of aging

  • WANG Tingxu ,
  • WANG Xu ,
  • ZHOU Lianyao ,
  • YIN Shuo ,
  • DAI Jingyu ,
  • YE Jing
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  • 1. Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China
    2. Shanghai Jiao Tong University, School of Biomedical Engineering, Shanghai 200241, China
    3. Shanghai Jiao Tong University School of Medicine, Department of Geriatrics, Medical Center on Aging of Shanghai Ruijin Hospital, Shanghai 200025, China

Received date: 2024-11-12

  Online published: 2026-04-08

Copyright

, 2025, Copyright reserved © 2025.
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摘要

随着我国人口老龄化程度不断加深，健康衰老与延缓衰老已成为重要社会议题。衰老进程存在个体异质性，受内在因素与外在因素共同调控。内在因素包括经典的十二大衰老特征，且通过多个衰老“时钟”可反映细胞衰老的水平，因此目前对内在因素的研究较为深入；外在因素包括促进因素和有害因素，目前对于外在因素的研究较少且更多集中于特定的风险领域，对真实世界的研究尚显不足。外在因素通过与内在因素的相互作用影响衰老。利用多变量交叉分析方法建立普遍环境下衰老内外因素交互作用的综合模型，能够为衰老及相关疾病的预防和早期预警提供理论支持与技术手段。

关键词： 衰老; 分子标志物; 环境

本文引用格式

王廷旭 , 王旭 , 周廉尧 , 尹硕 , 代敬宇 , 叶静 . 衰老异质性的研究进展[J]. 内科理论与实践, 2026 , 21(01) : 74 -79 . DOI: 10.16138/j.1673-6087.2026.01.11

Abstract

With the development of Chinese society, the proportion of the population aged 65 and above is increasing, and China is gradually entering an aging society. How to achieve healthy aging and how to delay aging have become important social issues. Due to the heterogeneity of aging, different individuals have different rates of aging. Aging is jointly regulated by internal and external factors. The internal factors include the twelve classic characteristics of aging, and there are multiple aging "clocks" that can indicate the level of cellular senescence. Therefore, the internal factors are clearly studied at present. The external factors include contributing factors and harmful factors. At present, the research on external factors is less and more concentrated in specific risk areas, and the research on the real situation is relatively limited. External factors interact with internal factors to influence aging. The use of multivariate cross analysis calculation to establish a comprehensive model of the interaction between internal and external factors of aging in a universal environment can provide theoretical support and technical means for the prevention and early warning of aging and related diseases.

Key words： aging; molecular marker; environment

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