内科理论与实践

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2026 , Vol. 21 >Issue 03: 277 - 283

DOI: https://doi.org/10.16138/j.1673-6087.2026.03.15

综述

低氧负荷在泛血管疾病风险评估中的研究进展

  • 吴静怡 ,
  • 施晟 ,
  • 张云云 ,
  • 崔小川
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  • 南京医科大学附属无锡人民医院全科医学科，江苏 无锡　214023
作者贡献/Authors’ Contributions吴静怡负责选题设计、 文献检索与整理、文献分析、论文撰写与修订及学术问题核查；施晟负责文献筛选、文献整理、归纳分析；张云云负责提出思路与概念框架、设计论文框架、对论文进行审阅与指导；崔小川负责提出研究总体思路、研究设计指导、对关键学术内容进行修改与把关、最终审阅、对文章负责及承担通信联络。
崔小川 E-mail：cuixiaochuan@njmu.edu.cn

收稿日期: 2025-06-05

  修回日期: 2025-08-29

  录用日期: 2025-09-16

  网络出版日期: 2026-08-19

基金资助

无锡市科技发展基金项目(K20221023)

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版权所有 © 2026 内科理论与实践编辑部
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Research progress on hypoxic burden in the risk assessment of panvascular diseases

  • WU Jingyi ,
  • SHI Sheng ,
  • ZHANG Yunyun ,
  • CUI Xiaochuan
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  • Department of General Medicine, Wuxi People's Hospital, Nanjing Medical University, Wuxi 214023, China

Received date: 2025-06-05

  Revised date: 2025-08-29

  Accepted date: 2025-09-16

  Online published: 2026-08-19

Copyright

Copyright © 2026 Journal of Internal Medicine Concepts & Practice. All rights reserved.
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摘要

泛血管疾病指以动脉粥样硬化（atherosclerosis, AS）为特征的一组具有共同病因的血管疾病，可影响包括大脑、心脏、肾脏等重要器官及四肢在内的多个关键部位。间歇性低氧（intermittent hypoxia，IH）可参与泛血管疾病发生发展，并与部分不良临床结局相关。近年来，低氧负荷（hypoxic burden, HB）作为评估IH严重程度的新型指标，在泛血管疾病临床评估中的价值逐渐受到关注。本文就HB在心血管、脑血管、慢性肾脏病等泛血管疾病发生发展及临床不良结局评估中的应用价值相关研究进行综述。

关键词： 阻塞性睡眠呼吸暂停; 生物标志物; 间歇性低氧; 泛血管疾病

本文引用格式

吴静怡 , 施晟 , 张云云 , 崔小川 . 低氧负荷在泛血管疾病风险评估中的研究进展[J]. 内科理论与实践, 2026 , 21(03) : 277 -283 . DOI: 10.16138/j.1673-6087.2026.03.15

Abstract

Panvascular diseases refer to a group of vasculopathies sharing common etiological factors, characterized by atherosclerosis (AS), which can affect multiple essential sites including vital organs such as the brain, heart, and kidneys, as well as the limbs. Intermittent hypoxia (IH) can readily exacerbate the progression of panvascular diseases. In recent years, hypoxic burden (HB) has emerged as a novel metric for assessing IH severity, garnering increasing attention for its clinical value in evaluating panvascular diseases. This review synthesizes current research on the application value of HB in evaluating the pathogenesis, progression, and adverse clinical outcomes of panvascular diseases, including cardiovascular, cerebrovascular, and chronic kidney diseases.

Key words： obstructive sleep apnea; biomarkers; intermittent hypoxia; panvascular disease

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