Journal of Internal Medicine Concepts & Practice >

2025 , Vol. 20 >Issue 04: 296 - 300

DOI: https://doi.org/10.16138/j.1673-6087.2025.04.06

Original article

Screening of risk or protective factors for prognosis and their interaction in elderly patients with stroke

  • XU Ting ,
  • RONG Jieli ,
  • GU Renli ,
  • XU Yang ,
  • LIU Xiaojiang
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  • a. Department of Neurosurgery, Hai’an People’s Hospital, Hai’an 226600, China
    b. Department of Trauma, Hai’an People’s Hospital, Hai’an 226600, China

Received date: 2024-07-17

  Online published: 2025-10-27

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Abstract

Objective To explore the risk or protective factors and their interactions for recurrence after acute ischemic stroke (AIS). Methods A total of 143 AIS patients admitted in our hospital from March 2020 to March 2023 were selected and followed up, and general clinical data were collected. Twelve patients were lost to follow-up. The end point of follow-up was stroke recurrence. The risk factors of stroke recurrence were screened by COX analysis, and the interaction between risk factors was analyzed. Results Univariate COX analysis showed that age, modified Rankin scale (mRS) score, the National Institutes of Health stroke scale (NIHSS) score, activated partial thrombin time and diabetes history were risk factors for poor prognosis in elderly patients with AIS [hazard ratio (HR) > 1, P < 0.05]. Montreal cognitive assessment scale (MoCA) score and fibrinogen are protective factors for good prognosis in elderly patients with AIS (HR < 1, P > 0.05). Multivariate COX analysis showed that mRS score and NIHSS score were independent risk factors for poor prognosis in elderly patients with AIS (HR > 1, P > 0.05). MoCA score and fibrinogen are protective factors for good prognosis in elderly patients with AIS (HR < 1, P > 0.05). Patients with high mRS score and high NIHSS score had worse prognosis (P < 0.001). Patients with high MoCA score and high fibrinogen level had better prognosis (P < 0.001). mRS score, NIHSS score, MoCA score and fibrinogen level had no significant interaction. Conclusions mRS score and NIHSS score are independent risk factors for poor prognosis in elderly patients with AIS. MoCA score and independent protective factor of good prognosis in elderly patients with AIS of fibrinogen. There was no significant interaction between these risk factors and protective factors.

Key words： Elderly; Acute ischemic stroke; Recurrence; Risk factor

Cite this article

XU Ting , RONG Jieli , GU Renli , XU Yang , LIU Xiaojiang . Screening of risk or protective factors for prognosis and their interaction in elderly patients with stroke[J]. Journal of Internal Medicine Concepts & Practice, 2025 , 20(04) : 296 -300 . DOI: 10.16138/j.1673-6087.2025.04.06

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