Objective To develop a scientifically reasonable set of sensitivity indicators for perioperative nursing quality in percutaneous coronary intervention (PCI). Methods Domestic and international literature was retrieved, and the Johns Hopkins evidence-based nursing practice model was employed to appraise the literature and grade the evidence. Indicators were screened and integrated to form a preliminary pool of sensitivity indicators for PCI perioperative nursing quality. Based on the theoretical basis of the Donabedian three-dimensional quality model, the Delphi method was utilized for expert consultation to construct the final indicator set. Results The response rates for both rounds of the expert consultation were 100%. The expert authority coefficients were both 0.889. The overall Kendall’ s coefficient of concordance were 0.496 and 0.523, respectively (P < 0.001). The final set of PCI perioperative nursing quality sensitivity indicators comprises 3 first-level, 13 second-level and 36 third-level indicators.Conclusions The developed sensitivity indicators for PCI perioperative nursing quality encompass multiple dimensions, including human resources, management systems, medical specialty training, nursing competency, medication and facility management, health education, preoperative/intraoperative/postoperative management, patient satisfaction, incidence of adverse events, nursing efficiency, and continuity of care. This indicator system can comprehensively measure PCI perioperative nursing quality and serves as a valuable tool for improving the overall standard of PCI perioperative nursing services.