胰腺癌新辅助治疗若干问题思考：从循证医学到精准医疗的范式转换

doi:10.16139/j.1007-9610.2025.06.03

摘要/Abstract

摘要：

胰腺癌新辅助治疗正经历从传统化疗向精准医疗的重大转变。本文从循证医学角度出发，结合最新临床研究进展，深入探讨胰腺癌新辅助治疗的前沿问题。重点关注免疫治疗联合策略、液体活检技术应用、人工智能（AI）辅助决策、个体化精准医疗等创新方向，并提出基于分子分型的个体化治疗策略、多组学整合的疗效预测模型以及标准化多学科协作诊疗体系等前瞻性观点。这些创新理念将推动胰腺癌新辅助治疗向更加精准、有效的方向发展。

关键词: 胰腺癌, 新辅助治疗, 精准医疗, 免疫治疗, 液体活检, 人工智能

Abstract:

Neoadjuvant therapy for pancreatic cancer is undergoing a paradigm shift from conventional chemotherapy to precision medicine. This expert forum discussed cutting-edge issues in pancreatic cancer neoadjuvant therapy from an evidence-based perspective, incorporating the latest clinical research advances. We focused on innovative directions including immunotherapy combination strategies, liquid biopsy applications, artificial intelligence (AI)-assisted decision making, and individualized precision medicine. We proposed forward-looking concepts such as molecular subtyping-guided individualized treatment strategies, multi-omics integrated efficacy prediction models, and standardized multidisciplinary collaborative care systems. These innovative concepts will drive pancreatic cancer neoadjuvant therapy toward more precise and effective directions.

Key words: Pancreatic cancer, Neoadjuvant therapy, Precision medicine, Immunotherapy, Liquid biopsy, Artificial intelligence（AI）

中图分类号:

R735.9

康晓超, 李轶楷, 郭世伟, 金钢. 胰腺癌新辅助治疗若干问题思考：从循证医学到精准医疗的范式转换[J]. 外科理论与实践, 2025, 30(06): 474-478.

KANG Xiaochao, LI Yikai, GUO Shiwei, JIN Gang. Reflections on key issues in neoadjuvant therapy for pancreatic cancer: a paradigm shift from evidence-based medicine to precision medicine[J]. Journal of Surgery Concepts & Practice, 2025, 30(06): 474-478.

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