中药槐耳治疗消化系统恶性肿瘤的研究进展

doi:10.16139/j.1007-9610.2026.02.13

摘要/Abstract

摘要：

消化系统恶性肿瘤发病率与死亡率较高，且近年来呈现年轻化趋势。尽管目前以手术切除为基础，联合新辅助放化疗、术后放化疗、靶向治疗和免疫治疗的综合治疗模式取得较大的突破，部分病人因耐药、分期晚或耐受差而预后不佳。槐耳作为一种传统中草药，已被用于消化系统恶性肿瘤的一线和辅助治疗，表现出一定的抑癌作用。近年来，多项体外实验证实了其部分抑癌作用机制，包括影响肿瘤细胞的干性，诱导肿瘤细胞死亡和调节肿瘤微环境等。本文总结了槐耳抗肿瘤分子作用机制的研究现状，强调槐耳治疗消化系统恶性肿瘤的潜力。此外，还综述了槐耳在不同消化系统恶性肿瘤中的治疗效果及相关分子机制，为其临床应用提供理论支持，对进一步研究槐耳的抑癌作用提出建议，为未来消化系统恶性肿瘤的综合治疗提出新方向。

关键词: 槐耳, 消化系统恶性肿瘤, 肿瘤干性, 肿瘤细胞死亡, 肿瘤微环境

Abstract:

Malignant tumors of the digestive system are associated with high morbidity and mortality rates, and their incidence has been increasing among younger populations in recent years. Although current comprehensive treatment strategies, which are primarily based on surgical resection and integrated with neoadjuvant chemoradiotherapy, postoperative chemoradiation, targeted therapy, and immunotherapy, have achieved substantial progress, the prognosis for certain patients remains poor due to drug resistance, advanced disease stages, or poor treatment tolerance. Vanderbylia robiniophila, a traditional Chinese herbal medicine, has been utilized as both a first-line and adjunctive therapeutic agent for digestive system malignancies, and has demonstrated notable antitumor efficacy. In recent years, multiple in vitro studies have elucidated several underlying antitumor mechanisms, including modulation of tumor cell stemness, induction of tumor cell death, and regulation of the tumor microenvironment. This review summarized the current understanding of the molecular mechanisms through which Vanderbylia robiniophila exerts its antitumor effects, highlighting its considerable therapeutic potential in digestive system malignancies. In addition, it provided a comprehensive overview of the therapeutic efficacy and corresponding molecular mechanisms of Vanderbylia robiniophila across various digestive system cancers, thereby providing theoretical support for its clinical application. Furthermore, this review proposes future research directions to further elucidate the antitumor properties of Vanderbylia robiniophila, aiming to inform and inspire novel strategies for the comprehensive treatment of digestive system malignancies.

Key words: Vanderbylia robiniophila, Malignant tumor of digestive system, Tumor stemness, Tumor cell death, Tumor microenvironment(TME)

中图分类号:

R735
R932

陆亭谚, 赵浩然, 石松畅, 李宗耀, 邵岩飞, 陈敬贤, 孙晶. 中药槐耳治疗消化系统恶性肿瘤的研究进展[J]. 外科理论与实践, 2026, 31(02): 175-182.

LU Tingyan, ZHAO Haoran, SHI Songchang, LI Zongyao, SHAO Yanfei, CHEN Jingxian, SUN Jing. Progress of traditional Chinese herbal medicine Vanderbylia robiniophila in the treatment of malignant tumors of digestive system[J]. Journal of Surgery Concepts & Practice, 2026, 31(02): 175-182.

图/表 4

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