专家论坛

直肠癌治疗器官保留策略:馅饼还是陷阱?

  • 周驿航 ,
  • 曾子威 ,
  • 康亮
展开
  • 中山大学附属第六医院结直肠外科 广东省胃肠病研究所 广东省结直肠盆底疾病研究重点实验室,广东 广州 510655
康亮,E-mail: kangl@mail.sysu.edu.cn

收稿日期: 2024-07-19

  网络出版日期: 2025-01-23

基金资助

中山大学临床医学研究5010计划资助(2016005);国家临床重点专科

Organ preservation strategies for rectal cancer treatment: tarts or trap?

  • ZHOU Yihang ,
  • ZENG Ziwei ,
  • KANG Liang
Expand
  • Department of Colorectal Surgery, Guangdong Institute of Gastroenterology,Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, the Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong Guangzhou 510655, China

Received date: 2024-07-19

  Online published: 2025-01-23

摘要

全直肠系膜切除术(TME)是进展期中低位直肠癌治疗的金标准。然而,由之而来的手术并发症发生及相应器官功能受损限制了该术式的应用。近年来,随着新辅助放化疗的进步以及免疫治疗的逐步应用,直肠癌新辅助治疗后病理完全缓解率不断提升。对于这部分病人是否仍需行TME产生质疑,因此,不行根治性手术的器官保留策略开始进入临床研究应用。目前有限的研究表明,无论是观察等待还是局部切除,虽然在部分病人中获得良好的长期生存并减少手术并发症发生和受损缺陷的优势,但还有临床完全缓解难以精准评估以及局部再发率过高导致长期生存下降等不足。仍需要进一步加强器官保留策略的探索研究,针对临床病例谨慎思考,以免该策略由“馅饼”变成“陷阱”。

本文引用格式

周驿航 , 曾子威 , 康亮 . 直肠癌治疗器官保留策略:馅饼还是陷阱?[J]. 外科理论与实践, 2024 , 29(05) : 396 -400 . DOI: 10.16139/j.1007-9610.2024.05.05

Abstract

Total mesorectal excision (TME) is the standard treatment for advanced mid- and low-rectal cancer. However, the associated surgical complications and subsequent impairment of organ function limit its application. In recent years, with advancements in neoadjuvant chemoradiotherapy and the implementation of immunotherapy, the pathological complete response (pCR) rate following neoadjuvant therapy for rectal cancer has significantly increased. This has raised questions about the necessity of performing TME in patients who achieve pCR. So as to, the clinical exploration of organ preservation strategies without radical surgery has been used in clinic. Current limited studies indicated that approaches such as watch & wait (W&W) or local excision have shown promising results in terms of long-term survival, and reduced surgical complications and functional impairment in some patients. However, challenges remain, including the difficulty in accurately assessing clinical complete response and the high rate of local recurrence, which could potentially compromise long-term survival. Further research into organ preservation strategies is needed, and careful consideration should be given to individual cases to prevent these strategies from becoming more of a “trap” than a “tart”.

参考文献

[1] 闫超, 陕飞, 李子禹. 2020年中国与全球结直肠癌流行概况分析[J]. 中华肿瘤杂志, 2023, 45(3):221-229.
  YAN C, SHAN F, LI Z Y. Prevalence of colorectal cancer in 2020: a comparative analysis between China and the world[J]. Chin J Oncol, 2023, 45(3):221-229.
[2] BENSON A B, VENOOK A P, AL-HAWARY M M, et al. Rectal cancer, version 2.2022, NCCN clinical practice guidelines in oncology[J]. J Natl Compr Canc Netw, 2022, 20(10):1139-1167.
[3] HEALD R J. The ‘Holy Plane’ of rectal surgery[J]. J R Soc Med, 1988, 81(9):503-508.
[4] GARFINKLE R, BOUTROS M. Low anterior resection syndrome: predisposing factors and treatment[J]. Surg Oncol, 2022,43:101691.
[5] KEANE C, WELLS C, O'GRADY G, et al. Defining low anterior resection syndrome: a systematic review of the literature[J]. Colorectal Dis, 2017, 19(8):713-722.
[6] BATTERSBY NJ, JUUL T, CHRISTENSEN P, et al. Predicting the risk of bowel-related quality-of-life impairment after restorative resection for rectal cancer: a multicenter cross-sectional study[J]. Dis Colon Rectum, 2016, 59(4):270-280.
[7] FLEMING C A, CULLINANE C, LYNCH N, et al. Urogenital function following robotic and laparoscopic rectal cancer surgery: meta-analysis[J]. Br J Surg, 2021, 108(2):128-137.
[8] SAUER R, BECKER H, HOHENBERGER W, et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer[J]. N Engl J Med, 2004, 351(17):1731-1740.
[9] KAPITEIJN E, MARIJNEN C A, NAGTEGAAL I D, et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer[J]. N Engl J Med, 2001, 345(9):638-646.
[10] Globalsurg Collaborative and National Institute for Health Research Global Health Research Unit On Global Surgery. Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries[J]. Lancet, 2021, 397(10272):387-397.
[11] OVERMAN M J, MCDERMOTT R, LEACH J L, et al. Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study[J]. Lancet Oncol, 2017, 18(9):1182-1191.
[12] HABR-GAMA A, PEREZ R O, NADALIN W, et al. Operative versus nonoperative treatment for stage 0 distal rectal cancer following chemoradiation therapy: long-term results[J]. Ann Surg, 2004, 240(4):711-717;discussion717-718.
[13] VAN DER VALK M J M, HILLING D E, BASTIAANNET E, et al. Long-term outcomes of clinical complete responders after neoadjuvant treatment for rectal cancer in the International Watch & Wait Database (IWWD): an international multicentre registry study[J]. Lancet, 2018, 391(10139):2537-2545.
[14] HABR-GAMA A, GAMA-RODRIGUES J, S?O JULI?O G P, et al. Local recurrence after complete clinical response and watch and wait in rectal cancer after neoadjuvant chemoradiation: impact of salvage therapy on local disease control[J]. Int J Radiat Oncol Biol Phys, 2014, 88(4):822-828.
[15] LIN W, WEE I J Y, SEOW-EN I, et al. Survival outcomes of salvage surgery in the watch-and-wait approach for rectal cancer with clinical complete response after neoadjuvant chemoradiotherapy: a systematic review and meta-analysis[J]. Ann Coloproctol, 2023, 39(6):447-456.
[16] LIM L, CHAO M, SHAPIRO J, et al. Long-term outcomes of patients with localized rectal cancer treated with chemoradiation or radiotherapy alone because of medical inoperability or patient refusal[J]. Dis Colon Rectum, 2007, 50(12):2032-2039.
[17] ARAUJO R O, VALAD?O M, BORGES D, et al. Non-operative management of rectal cancer after chemoradiation opposed to resection after complete clinical response. A comparative study[J]. Eur J Surg Oncol, 2015, 41(11):1456-1463.
[18] FERNANDEZ L M, S?O JULI?O G P, RENEHAN A G, et al. The risk of distant metastases in patients with clinical complete response managed by watch and wait after neoadjuvant therapy for rectal cancer: the influence of local regrowth in the international watch and wait database[J]. Dis Colon Rectum, 2023, 66(1):41-49.
[19] GARCIA-AGUILAR J, RENFRO L A, CHOW O S, et al. Organ preservation for clinical T2N0 distal rectal cancer using neoadjuvant chemoradiotherapy and local excision (ACOSOG Z6041): results of an open-label, single-arm, multi-institutional, phase 2 trial[J]. Lancet Oncol, 2015, 16(15):1537-1546.
[20] RULLIER E, ROUANET P, TUECH J J, et al. Organ preservation for rectal cancer (GRECCAR 2): a prospective, randomised, open-label, multicentre, phase 3 trial[J]. Lancet, 2017, 390(10093):469-479.
[21] VERSEVELD M, DE GRAAF E J, VERHOEF C, et al. Chemoradiation therapy for rectal cancer in the distal rectum followed by organ-sparing transanal endoscopic microsurgery (CARTS study)[J]. Br J Surg, 2015, 102(7):853-860.
文章导航

/