目的：评估焦虑水平与甲状腺乳头状癌(PTC)病人各项临床及病理特征之间的关系。方法：2022年7月至2023年9月期间，在本中心接受手术治疗的病人中，有304例接受汉密尔顿焦虑量表(HAM-A)问卷调查，回顾性分析其临床及病理特征，并分析与焦虑水平的关系。结果：304例病人中，有271例经病理证实为PTC。其中75例处于较高的焦虑水平（根据HAM-A评分标准，≥14提示具有临床意义的焦虑症状），为焦虑组。单因素统计分析显示，焦虑组的甲状腺过氧化物酶抗体(TPOAb)异常升高的比例高于无焦虑组（34.7%比16.8%，P=0.002 4）。焦虑组肿瘤多灶性的比例也高于无焦虑组（33.3%比16.7%，P=0.004 4）。多因素Logistic回归分析证实焦虑水平与TPOAb异常升高及肿瘤多灶性相关（P=0.005 6，0.001 9）。结论：焦虑水平可能与PTC病人的TPOAb异常升高及肿瘤多灶性相关。

Objective To evaluate the relationship between anxiety levels and clinicopathological characteristics in patients with papillary thyroid carcinoma (PTC). Methods Among the patients who underwent surgical treatment in our center from July 2022 to September 2023, 304 patients completed the Hamilton anxiety rating scale (HAM-A) questionnaire. The clinical and pathological characteristics of these patients and their association with anxiety levels were investigated. Results Among the 304 patients, 271 were pathologically confirmed to have PTC. Of the 271 patients, 75 had higher levels of anxiety (according to HAM-A scoring system, a score ≥14 indicates clinically significant anxiety) and were assigned to the anxiety group. Univariate statistical analysis showed that the proportion of patients with elevated thyroid peroxidase antibody (TPOAb) in the anxiety group was higher than that in the non-anxiety group (34.7% vs. 16.8%, P=0.002 4). Moreover, the proportion of patients with multifocal tumors in the anxiety group was also higher than that in the non-anxiety group (33.3% vs. 16.7%, P=0.004 4). Multivariate Logistic regression confirmed that anxiety levels were associated with elevated TPOAb (P=0.005 6) and tumor multifocality (P=0.001 9). Conclusions Anxiety levels may be related to elevated TPOAb and tumor multifocality in PTC patients.