外科理论与实践

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2026 , Vol. 31 >Issue 02: 129 - 136

DOI: https://doi.org/10.16139/j.1007-9610.2026.02.06

论著

腹腔镜胃旁路术治疗肥胖合并多囊卵巢综合征疗效荟萃分析

  • 王书翰 ,
  • 任振 ,
  • 韦笑韩 ,
  • 刘虎 ,
  • 潘晨 ,
  • 吴立胜
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  • 1 蚌埠医科大学研究生院， 安徽 蚌埠 233030
    2 皖南医学院研究生院， 安徽 芜湖 241002
    3 中国科学技术大学附属第一医院（安徽省立医院）疝及肥胖外科， 安徽 合肥 230001
作者贡献/Authors’ contributions

王书翰负责文献筛选、数据采集、数据分析、图表的制作和文章初步撰写；任振负责文献筛选、数据分析与结果核对；韦笑韩、刘虎负责数据采集与核对；潘晨负责数据分析和图表制作的指导；吴立胜负责文章总体设计、修改及指导。所有作者均阅读并确认最终稿。

吴立胜，E-mail: wlsheng1210@163.com

收稿日期: 2025-04-08

  网络出版日期: 2026-06-23

基金资助

吴阶平医学基金会临床科研专项基金资助项目(320.6750.2022-07-7)

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Meta-analysis of the therapeutic effect of LRYGB in patients with obesity-related polycystic ovary syndrome

  • WANG Shuhan ,
  • REN Zhen ,
  • WEI Xiaohan ,
  • LIU Hu ,
  • PAN Chen ,
  • WU Lisheng
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  • 1 Graduate School of Bengbu Medical College, Anhui Bengbu 233030, China
    2 Graduate School of Wannan Medical College, Anhui Wuhu 241002, China
    3 Department of Hernia and Obesity Surgery, the First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Anhui Hefei 230001, China

Received date: 2025-04-08

  Online published: 2026-06-23

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摘要

目的：系统评估腹腔镜Roux-en-Y胃旁路术（LRYGB）对肥胖合并多囊卵巢综合征（PCOS）病人的疗效。方法：通过检索PubMed、Embase、Web of Science及Scopus数据库，筛选出截至2025年1月1日前的相关研究。依预设纳入和排除标准筛选后共纳入6项研究128例病人。结果：LRYGB术后月经紊乱病人显著减少(OR=0.07; 95%CI: 0.04~0.14; P<0.05)；多毛症（OR=0.14; 95%CI: 0.06~0.32; P<0.05）、性激素结合球蛋白（SHBG）（MD=23.24; 95%CI: 7.97~38.51; P<0.05）、游离雄激素指数(FAI)（MD=-3.89; 95%CI: -5.33~-2.45； P<0.05）、总睾酮(MD=-25.55; 95%CI: -30.08~-21.01; P<0.05)和体质量指数(BMI)（MD=-17.22；95% CI: -19.32~-15.11；P<0.000 1）均显著改善。结论：LRYGB可作为一种有效的治疗手段改善肥胖合并PCOS人群的体重和代谢情况。

关键词： 减重手术; 腹腔镜Roux-en-Y胃旁路术; 多囊卵巢综合征; 肥胖症

本文引用格式

王书翰 , 任振 , 韦笑韩 , 刘虎 , 潘晨 , 吴立胜 . 腹腔镜胃旁路术治疗肥胖合并多囊卵巢综合征疗效荟萃分析[J]. 外科理论与实践, 2026 , 31(02) : 129 -136 . DOI: 10.16139/j.1007-9610.2026.02.06

Abstract

Objective To systematically evaluate the therapeutic effect of laparoscopic Roux-en-Y gastric bypass (LRYGB) in patients with obesity comorbid with polycystic ovary syndrome (PCOS). Methods A systematic literature search was conducted across four databases (PubMed, Embase, Web of Science, and Scopus) for studies published up to January 1, 2025. Following screening against predefined eligibility criteria, a total of 6 studies comprising 128 patients were ultimately included. Results Following LRYGB, there was a significant reduction in the number of patients with menstrual irregularities (OR=0.07; 95%CI: 0.04~0.14; P<0.05). Additionally, significant improvements were observed in hirsutism (OR=0.14; 95%CI: 0.06~0.32; P<0.05), sex hormone-binding globulin (SHBG) (MD=23.24; 95%CI: 7.97~38.51; P<0.05), free androgen index (FAI) (MD=-3.89; 95%CI: -5.33~-2.45; P<0.05), total testosterone levels (MD=-25.55; 95%CI: -30.08~-21.01; P<0.05), and body mass index (BMI) (MD=-17.22; 95%CI: -19.32~-15.11; P<0.000 1). Conclusions LRYGB can serve as an effective therapeutic intervention to improve body weight and metabolic profiles in the population with obesity comorbid with PCOS.

Key words： Bariatric surgery; Laparoscopic Roux-en-Y gastric bypass (LRYGB); Polycystic ovary syndrome(PCOS); Obesity

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