目的：探讨肠壁侵犯深度对接受肠段切除术的卵巢癌肠道转移病人预后的影响。方法：回顾性分析2013年10月至2025年3月于上海瑞金医院行肿瘤细胞减灭术联合肠段切除术的65例上皮性卵巢癌病人的临床病理资料。根据肠壁侵犯深度分为浆膜/肌层侵犯组（47例）和黏膜/黏膜下层侵犯组（18例），比较两组临床病理特征及无进展生存期(PFS)的差异。结果：黏膜/黏膜下层侵犯组中位PFS显著长于浆膜/肌层侵犯组（51.6个月比27.2个月，P=0.014）。与浆膜/肌层侵犯组相比，黏膜/黏膜下层侵犯组初诊时CA125较低（300.5 U/mL比1 050.0 U/mL，P=0.034），术前影像学肠道转移灶检出率较高（100%比48.9%，P<0.001），初诊时合并大腹水比例较低（11.1% 比48.9%，P=0.005），术中腹膜癌指数（PCI）较低（8.7±4.6 比13.4±6.5，P=0.007）。两组在手术相关指标及围术期并发症方面的差异均无统计学意义（均P>0.05）。结论：对于接受肠段切除术的卵巢癌肠道转移病人，肠壁侵犯深度与预后密切相关。侵犯至黏膜/黏膜下层者预后较好，其肿瘤的盆腹腔种植转移能力相对较弱。故术前精准评估肠壁侵犯深度有助于优化手术策略。

Objective To investigate the impact of depth of bowel wall invasion on clinical characteristics and prognosis in ovarian cancer patients with intestinal metastasis undergoing bowel resection. Methods A retrospective analysis was conducted on 65 patients with epithelial ovarian cancer who underwent cytoreductive surgery combined with bowel resection at Shanghai Ruijin Hospital from October 2013 to March 2025. Patients were divided into two groups according to the depth of bowel wall invasion: the serosa/muscularis invasion group (n=47) and the mucosa/submucosa invasion group (n=18). Clinicopathological characteristics and progression-free survival (PFS) were compared between the two groups. Results The median PFS was significantly longer in the mucosa/submucosa invasion group than in the serosa/muscularis invasion group (51.6 months vs. 27.2 months, P=0.014). Compared with the serosa/muscularis invasion group, the mucosa/submucosa invasion group had lower serum CA125 levels at initial diagnosis (300.5 U/mL vs. 1 050.0 U/mL, P=0.034), a higher rate of preoperative imaging detection of intestinal metastasis (100% vs. 48.9%, P<0.001), a lower proportion of patients with massive ascites at initial diagnosis (11.1% vs. 48.9%, P=0.005), and the intraoperative peritoneal cancer index (PCI) was also lower (8.7±4.6 vs. 13.4±6.5, P=0.007). No statistically significant differences were observed between the two groups in terms of surgery-related indicators and perioperative complications (all P>0.05). Conclusions In patients with ovarian cancer intestinal metastasis undergoing bowel resection, depth of bowel wall invasion is closely associated with prognosis. Those with invasion reaching the mucosa/submucosa have better prognosis and a relatively weak ability for abdominopelvic seeding. Thus, precise preoperative assessment of invasion depth may help optimize surgical strategies.