Objective To evaluate the safety, feasibility and clinical efficacy of single-port laparoscopy in the treatment of colorectal cancer. Methods From January 2017 to December 2017, a retrospective study was conducted with patients diagnosed as colorectal cancer in Department of General Surgery Ruijin Hospital North Shanghai Jiao Tong University School of Medicine. Patients were divided into single-port group and three-port group. The operative time, intraoperative blood loss, lymph node harvest, postoperative complication rate, gastrointestinal recovery, local recurrence, distant metastasis were compared between two groups. Results There were 78 patients with laparoscopic radical resection of co-lorectal cancer including 40 cases in single-port group and 38 cases in three-port group. Four patients added port and 1 patient converted to open surgery in single-port group. Three patients in three-port group added port without conversion to open events. There were no ureter or vaginal injuries and no colostomy procedure during operation. The operative time was (106.38±; 30.21) min and (109.49±; 34.93) min, and intraoperative blood loss（59.62±; 11.93） mL and （42.63±; 6.62） mL and single-port group and three-port group respectively without statistical difference. There was significant difference of postoperative evacuation time between 2 groups [(3.15±; 1.08) d vs (3.97±; 1.03) d (P<; 0.01)]. Mean time of pain score (VAS) reduced to less than levelⅠwas (1.40±; 0.50) d vs (4.11±; 0.89) d in 2 groups respectively (P<; 0.01). Surgical margins in all cases were negative and the specimens all met the requirements of complete resection. The number of lymph nodes detected in 2 groups was (13.70±; 2.93) and (12.66±; 1.55) without statistical difference. There was no severer complication such as anastomotic leakage in all cases postoperatively, and 1 case with incision infection occurred in single-port group. No tumor recurrence or metastasis was observed during the period of follow-up from 6 to 18 month. Conclusions Single-port laparoscopic colorectal cancer surgery could be safe and radical same as three-port laparoscopic surgery with faster postoperative gastrointestinal recovery and shorter pain time.
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