Objective To investigate differences in clinicopathological features and prognosis between invasive micropapillary mucinous carcinoma (IMpMC) and pure mucinous carcinoma (PMC) of breast. Methods The patients of IMpMC and those of PMC were enrolled in this study retrospectively with clinicopathological and follow-up data from Shanghai Jiao Tong University Breast Cancer Database (SJTU-BCDB) between September 2008 and December 2017. Differences in clinicopathology and prognosis between IMpMC and PMC were analyzed. Results A total of 239 patients were enrolled including 27 (11.3%) cases with IMpMC and 212 (88.7%) cases with PMC. Multivariate analysis on clinicopathological feature showed that there were more cases with IMpMC with lymph node metastasis (OR=4.84, P=0.014), lymphovascular invasion (OR=13.38, P=0.001) and higher expression of Ki67 (OR=4.07, P=0.044) when compared the patients with PMC. Multivariate analysis on treatment showed that radical mastectomy for breast cancer (OR=10.00, P=0.003), adjuvant chemotherapy (OR=7.11, P<0.001) and radiotherapy (OR=5.33, P=0.006) were performed for more cases with IMpMC than for cases with PMC. PMC patients had higher disease free survival (DFS) 92.5% and overall survival (OS) 98.6%, compared to IMpMC patients (DFS 79.2%, P=0.011, OS 93.8%, P=0.022). Pathological type and tumor size were independent factors associated with DFS shown in multivariate analysis. IMpMC patients had lower DFS than PMC patients (HR=10.39, P=0.014). Conclusions IMpMC was associated with aggressive behavior and worse prognosis when compare to PMC.
CHEN Shujie, CHEN Xiaosong, JI Min, SHAO Yuguo, SHEN Kunwei, HE Qi
. Analysis of invasive micropapillary mucinous carcinoma of breast[J]. Journal of Surgery Concepts & Practice, 2019
, 24(05)
: 440
-445
.
DOI: 10.16139/j.1007-9610.2019.05.014
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