Journal of Surgery Concepts & Practice >

2021 , Vol. 26 >Issue 06: 543 - 549

DOI: https://doi.org/10.16139/j.1007-9610.2021.06.017

Original article

Expression of chemokine CXCL5 and programme death ligand 1 in colorectal cancer tissues are associated with prognosis of patients

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  • Department of Surgery, Ruijin Hospital, Shanghai JiaoTong University School of Medicine，Shanghai Minimally Invasive Surgery Center, Shanghai 200025, China

Received date: 2020-05-09

  Online published: 2022-07-27

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Abstract

Objective To analyze the expression of CXCL5 (C-X-C motif ligand 5) and programme death ligand 1 (PD-L1) in colorectal cancer tissues and explore two chemokines associated with clinical characteristics and prognosis. Methods The specimens of tumor tissues and adjacent normal tissues were collected from 78 patients with colorectal cancer who had laparoscopic resection from 2010 to 2011. The clinical data were gotten and follow-up were done for prognosis. Tissue microarrays were made from all specimens and immunohistochemical staining was performed. Expression of CXCL5 and PD-L1 was evaluated using immune risk scoring and analyzed with the association of clinical pathological parameters and prognosis of patients. Results Expression of CXCL5 and PD-L1 was associated with tumor size and TNM stage, and was higher in colorectal cancer tissues than in adjacent normal tissues. Cox univariate regression analysis showed that TNM stage, high expression of both CXCL5 and PD-L1 were the prognostic risk factors for overall survival of colorectal patients. It was shown with multivariate regression analysis that TNM stage and high expression of PD-L1 were the independent prognostic risk factors for overall survival rate. Patients with higher expression of both CXCL5 and PD-L1 had the worst prognosis. Conclusions CXCL5 combined with PD-L1 could stratify the risk of patients with colorectal cancer and predict the prognosis of patients.

Key words： Colorectal cancer; CXCL5; Programmed death ligand 1

Cite this article

LIU Shiguang, ZHAO Jingkun, LU Aiguo, MAO Zhihai . Expression of chemokine CXCL5 and programme death ligand 1 in colorectal cancer tissues are associated with prognosis of patients[J]. Journal of Surgery Concepts & Practice, 2021 , 26(06) : 543 -549 . DOI: 10.16139/j.1007-9610.2021.06.017

References

[1] Parkin DM, Bray F, Ferlay J, et al. Global cancer statistics, 2002[J]. CA Cancer J Clin, 2005, 55(2):74-108.
[2] 陈万青, 孙可欣, 郑荣寿, 等. 2014年中国分地区恶性肿瘤发病和死亡分析[J]. 中国肿瘤, 2018, 27(1):1-14.
[3] Hegde PS, Chen DS. Top 10 challenges in cancer immunotherapy[J]. Immunity, 2020, 52(1):17-35.
[4] Borsig L, Wolf MJ, Roblek M, et al. Inflammatory chemokines and metastasis-tracing the accessory[J]. Oncogene, 2014, 33(25):3217-3224.
[5] Stillie R, Farooq SM, Gordon JR, et al. The functional significance behind expressing two IL-8 receptor types on PMN[J]. J Leukoc Biol, 2009, 86(3):529-543.
[6] Arenberg DA, Keane MP, DiGiovine B, et al. Epithelial- neutrophil activating peptide (ENA-78) is an important angiogenic factor in non-small cell lung cancer[J]. J Clin Invest, 1998, 102(3):465-472.
[7] Begley LA, Kasina S, Mehra R, et al. CXCL 5 promotes prostate cancer progression[J]. Neoplasia, 2008, 10(3):244-254.
[8] Atanackovic D, Luetkens T, Kröger N. Coinhibitory molecule PD-1 as a potential target for the immunotherapy of multiple myeloma[J]. Leukemia, 2014, 28(5):993-1000.
[9] Zhao J, Ou B, Han D, et al. Tumor-derived CXCL5 promotes human colorectal cancer metastasis through activation of the ERK/Elk-1/Snail and AKT/GSK3β/β-catenin pathways[J]. Mol Cancer, 2017, 16(1):70.
[10] Hsu YL, Hou MF, Kuo PL, et al. Breast tumor-associated osteoblast-derived CXCL5 increases cancer progression by ERK/MSK1/Elk-1/snail signaling pathway[J]. Oncogene, 2013, 32(37):4436-4447.
[11] Sanchez-Lopez E, Flashner-Abramson E, Shalapour S, et al. Targeting colorectal cancer via its microenvironment by inhibiting IGF-1 receptor-insulin receptor substrate and STAT3 signaling[J]. Oncogene, 2016, 35(20):2634-2644.
[12] Chang MS, Mcninch J, Basu R, et al. Cloning and cha-racterization of the human neutrophil-activating peptide (ENA-78) gene[J]. J Biol Chem, 1994, 269(41):25277-25282.
[13] Walz A, Burgener R, Car B, et al. Structure and neutrophil-activating properties of a novel inflammatory peptide (ENA-78) with homology to interleukin 8[J]. J Exp Med, 1991, 174(6):1355-1362.
[14] Z′Graggen K, Walz A, Mazzucchelli L, et al. The C-X-C chemokine ENA-78 is preferentially expressed in intestinal epithelium in inflammatory bowel disease[J]. Gastroenterology, 1997, 113(3):808-816.
[15] Lu B, Chen L, Liu L, et al. T-cell-mediated tumor immune surveillance and expression of B7 co-inhibitory molecules in cancers of the upper gastrointestinal tract[J]. Immunol Res, 2011, 50(2-3):269-275.
[16] Hino R, Kabashima K, Kato Y, et al. Tumor cell expression of programmed cell death ligand-1 is a prognostic factor for malignant melanoma[J]. Cancer, 2010, 116(7):1757-1766.
[17] Hou J, Yu Z, Xiang R, et al. Correlation between infiltration of FOXP3+ regulatory T cells and expression of B7-H1 in the tumor tissues of gastric cancer[J]. Exp Mol Pathol, 2014, 96(3):284-291.
[18] Qin T, Zeng YD, Qin G, et al. High PD-L 1 expression was associated with poor prognosis in 870 Chinese patients with breast cancer[J]. Oncotarget, 2015, 6(32):33972-33981.
[19] Shi SJ, Wang LJ, Wang GD, et al. B7-H1 expression is associated with poor prognosis in colorectal carcinoma and regulates the proliferation and invasion of HCT116 colorectal cancer cells[J]. PLoS One, 2013, 8(10):e76012.
[20] Droeser RA, Hirt C, Viehl CT, et al. Clinical impact of programmed cell death ligand 1 expression in colorectal cancer[J]. Eur J Cancer, 2013, 49(9):2233-2242.
[21] Li Z, Zhou J, Zhang J, et al. Cancer-associated fibroblasts promote PD-L1 expression in mice cancer cells via secreting CXCL5[J]. Int J Cancer, 2019, 145(7):1946-1957.
[22] Wang Y, Zhuang Q, Zhou S, et al. Costimulatory molecule B7-H1 on the immune escape of bladder cancer and its clinical significance[J]. J Huazhong Univ Sci Technolog Med Sci, 2009, 29(1):77-79.
[23] Speetjens FM, Kuppen PJ, Sandel MH, et al. Disrupted expression of CXCL5 in colorectal cancer is associated with rapid tumor formation in rats and poor prognosis in patients[J]. Clin Cancer Res, 2008, 14(8):2276-2284.
[24] 李芮. 综合护理干预对烧伤患者趋势因子及创面愈合的影响[J]. 实用临床护理学杂志, 2017, 2(45):56-59.
[25] 焦海良, 朱斌, 苏瑞洋. 多学科协作诊治模式下结直肠癌术前辅助检查系统的临床应用初步探索[J]. 当代医学, 2017, 23(22):42-44.
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