Journal of Surgery Concepts & Practice >

2023 , Vol. 28 >Issue 05: 448 - 453

DOI: https://doi.org/10.16139/j.1007-9610.2023.05.10

Original article

Analysis of the effect of double filtration plasmapheresis on hyperlipidemic acute pancreatitis

Expand
  • Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Received date: 2023-08-16

  Online published: 2024-01-04

Fold

Abstract

Objective To evaluate the effect of double filtration plasmapheresis (DFPP) on patients with hyperlipidemic acute pancreatitis (HL-AP). Methods The clinical data of the patients with hyperlipidemic severe acute pancreatitis (HL-SAP) or moderately severe acute pancreatitis (HL-MSAP) from January 2019 to May 2022 were collected. The patients were divided into two groups,the control group received conventional treatment, DFPP group received DFPP treatment on the basis of conventional treatment. Results Compared with the control group, the following parameters changed significantly in DFPP group, triglyceride (TG), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) decreased on day 1 and 2, estimated glomerular filtration rate (eGFR) increased on day 1, 2, 3 and 5, leukocyte and neutrophil counts decreased on day 1 and 2, hemoglobin (HGB) decreased on day 1, 2, and 3, C-reactive protein (CRP) decreased on day 1, 2, 3, 5, and 7. And the patients in DFPP group receiving mechanical ventilation decreased compared with that in control group. Conclusion Compared with conventional treatment, DFPP can reduce plasma TG faster, improve lung, liver and kidney function, reduce inflammatory markers, and facilitate early fluid recovery.

Key words： Hyperlipidemic acute pancreatitis; Double filtration plasmapheresis; Multiple organ dysfunction syndrome

Cite this article

GE Yan, WANG Guoxin, WANG Jiahui, AN Yuan, ZHAO Bing, SHENG Huiqiu, MA Li . Analysis of the effect of double filtration plasmapheresis on hyperlipidemic acute pancreatitis[J]. Journal of Surgery Concepts & Practice, 2023 , 28(05) : 448 -453 . DOI: 10.16139/j.1007-9610.2023.05.10

References

[1] DE PRETIS N, DE MARCHI G, FRULLONI L. Hypertriglyceridemic pancreatitis[J]. Minerva Gastroenterol Dietol, 2020, 66(3):238-245.
[2] ZHU Y, PAN X, ZENG H, et al. A study on the etiology, severity, and mortality of 3260 patients with acute pancreatitis according to the revised atlanta classification in Jiangxi, China over an 8-year period[J]. Pancreas, 2017, 46(4):504-509.
[3] XIANG J X, HU L S, LIU P, et al. Impact of cigarette smoking on recurrence of hyperlipidemic acute pancreatitis[J]. World J Gastroenterol, 2017, 23(47):8387-8394.
[4] JIANG D, WANG J, GUO S. Correlations of triglyceride with type, severity and clinical prognosis of acute pancreatitis[J]. Clin Lab, 2022, 68(5).
[5] PU W, TANG W, SHEN Y, et al. Comparison of different intensive triglyceride-lowering therapies in patients with hyperlipidemic acute pancreatitis[J]. Pancreatology, 2023, 13:S1424- 3903(23)01789-1.
[6] GUO W X, LU X G, ZHAN L B, et al. Chinese herbal medicine therapy for hyperlipidemic acute pancreatitis: a systematic review and meta-analysis of randomized controlled trials[J]. Eur Rev Med Pharmacol Sci, 2023, 27(6):2256-2276.
[7] MORKOS M, AMBLEE A, HENRIQUEZ A, et al. External validation of a predictive model for acute pancreatitis risk in patients with severe hypertriglyceridemia[J]. Endocr Pract, 2019, 25(8):817-823.
[8] BIBERCI KESKIN E, KO?HAN K, K?KER ?H, et al. The role of plasma exchange in hypertriglyceridemia-induced acute pancreatitis[J]. Eur J Gastroenterol Hepatol, 2019, 31(6):674-677.
[9] XIA W, LU Z, CHEN W, et al. Excess fatty acids induce pancreatic acinar cell pyroptosis through macrophage M1 polarization[J]. BMC Gastroenterol, 2022, 22(1):72.
[10] BIYIK M, BIYIK Z, ASIL M, et al. Systemic inflammation response index and systemic immune inflammation index are associated with clinical outcomes in patients with acute pancreatitis?[J]. J Invest Surg, 2022, 35(8):1613-1620.
[11] MOSZTBACHER D, HANáK L, FARKAS N, et al. Hypertriglyceridemia-induced acute pancreatitis: a prospective, multicenter, international cohort analysis of 716 acute pancreatitis cases[J]. Pancreatology, 2020, 20(4):608-616.
[12] LIN Y F, YAO Y, XU Y, et al. Apheresis technique for acute hyperlipidemic pancreatitis: a systemic review and meta-analysis[J]. Dig Dis Sci, 2023, 68(3):948-956.
[13] YU S, YAO D, LIANG X, et al. Effects of different triglyceride-lowering therapies in patients with hypertriglyceridemia-induced acute pancreatitis[J]. Exp Ther Med, 2020, 19(4):2427-2432.
[14] FEI F, BOSHELL N, WILLIAMS L A 3rd. Predictability and efficacy of therapeutic plasma exchange for hypertriglyceridemia induced acute pancreatitis[J]. Transfus Apher Sci, 2020, 59:102699.
[15] YILDIRIM ?IM?IR I, SOYALTYN UE, SARER YüREKLI B, et al. Therapeutic plasma exchange in hypertriglyceridemic patients[J]. Turk J Med Sci, 2019, 49(3):872-878.
[16] GARG R, RUSTAGI T. Management of hypertriglyceridemia induced acute pancreatitis[J]. Biomed Res Int, 2018, 2018:4721357.
[17] ZHENG C B, ZHENG Z H, ZHENG Y P. Therapeutic plasma exchange for hyperlipidemic pancreatitis: current evidence and unmet needs[J]. World J Clin Cases, 2021, 9(21):5794-5803.
[18] DEHAL H, ADASHEK M. Total plasma exchange in hypertriglyceridemia-induced pancreatitis: case report and literature review[J]. Case Rep Med, 2018, 2018:4017573.
[19] EDEN G, GRADAUS F, BROWN K, et al. Therapeutic plasma exchange for the treatment of hypertriglyceridemia-induced pancreatitis: a case report[J]. Med Klin Intensivmed Notfmed, 2017, 112(5):471-474.
[20] GUDIVADA K K, KRISHNA B. Intensive insulin therapy and plasma exchange in hypertriglyceridaemic acute pancreatitis with multiple organ dysfunction[J]. Natl Med J India, 2019, 32(6):352-354.
Options
Outlines

/

〈 〉