Journal of Surgery Concepts & Practice >

2025 , Vol. 30 >Issue 06: 524 - 528

DOI: https://doi.org/10.16139/j.1007-9610.2025.06.11

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Advances of prevention and management for post-pancreatectomy acute pancreatitis

  • CHEN Haoda ,
  • SHEN Baiyong
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  • Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Pancreatic Neoplasms Translational Research, Research Institute of Pancreatic Diseases, Shanghai Jiao Tong University School of Medicine; State Key Laboratory of Systems Medicine for Cancer; Institute of Translational Medicine， Shanghai Jiao Tong University, Shanghai 200025, China

Received date: 2025-07-11

  Online published: 2026-01-26

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Abstract

Post-pancreatectomy acute pancreatitis (PPAP) is a common complication following pancreatic surgery, characterized primarily by early postoperative local and systemic inflammatory responses. These responses can trigger a series of subsequent complications, significantly impacting patient’s clinical outcomes. In recent years, PPAP has been recognized as a distinct postoperative complication, and the International Study Group of Pancreatic Surgery (ISGPS) has proposed standardized definitions and grading criteria for it, which required a combination of postoperative enzyme elevation, imaging features, and changes in clinical management. This has garnered widespread attention within the field of pancreatic surgery. The occurrence of PPAP is closely related to microcirculatory disturbances. Clinically, it can manifest as self-limiting inflammation and is closely associated with pancreatic fistula development. In some cases, it may progress to necrotizing pancreatitis, potentially requiring surgical intervention. Current prevention and management strategies focus on intraoperative preservation of pancreatic blood supply, perioperative use of anti-inflammatory medications, and symptomatic supportive care. However, the diagnostic criteria, pathogenesis, and comprehensive management framework for PPAP still require further research and refinement.

Key words： Post-pancreatectomy acute pancreatitis(PPAP); Postoperative complication; Pancreaticoduodenectomy(PD); Postoperative pancreatic fistula(POPF)

Cite this article

CHEN Haoda , SHEN Baiyong . Advances of prevention and management for post-pancreatectomy acute pancreatitis[J]. Journal of Surgery Concepts & Practice, 2025 , 30(06) : 524 -528 . DOI: 10.16139/j.1007-9610.2025.06.11

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