Journal of Surgery Concepts & Practice >

2025 , Vol. 30 >Issue 06: 544 - 550

DOI: https://doi.org/10.16139/j.1007-9610.2025.06.14

Review

Current status and reflections on immunotherapy and targeted therapy for unresectable biliary tract cancer

  • YU Liqin ,
  • YAN Xiaoyu ,
  • WANG Puxiongzhi ,
  • WANG Wei ,
  • WANG Jian
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  • Department of Hepatobiliary & Pancreatic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China

Received date: 2025-04-29

  Online published: 2026-01-26

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Abstract

Biliary tract cancer (BTC) represents a group of highly malignant solid tumors with a five-year survival rate of only 10%. For patients with unresectable BTC, gemcitabine combined with cisplatin has been the conventional first-line treatment regimen. With the remarkable efficacy of immunotherapy and targeted therapy observed in other solid tumors, numerous studies have investigated their potential in unresectable BTC. This article provides an overview of the current status of targeted and immunotherapeutic approaches for unresectable BTC, with a focus on research advancements in immune checkpoint inhibitor (ICI) and targeted agents against fibroblast growth factor receptor(FGFR), isocitrate dehydrogenase(IDH), and human epidermal growth factor receptor 2(HER2), as well as future trends in immunotherapy and targeted therapy, aiming to contribute to the development of more effective treatment strategies.

Key words： Biliary tract cancer; Immunotherapy; Targeted therapy; Biomarker

Cite this article

YU Liqin , YAN Xiaoyu , WANG Puxiongzhi , WANG Wei , WANG Jian . Current status and reflections on immunotherapy and targeted therapy for unresectable biliary tract cancer[J]. Journal of Surgery Concepts & Practice, 2025 , 30(06) : 544 -550 . DOI: 10.16139/j.1007-9610.2025.06.14

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