Journal of Surgery Concepts & Practice >

2026 , Vol. 31 >Issue 02: 129 - 136

DOI: https://doi.org/10.16139/j.1007-9610.2026.02.06

Original article

Meta-analysis of the therapeutic effect of LRYGB in patients with obesity-related polycystic ovary syndrome

  • WANG Shuhan ,
  • REN Zhen ,
  • WEI Xiaohan ,
  • LIU Hu ,
  • PAN Chen ,
  • WU Lisheng
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  • 1 Graduate School of Bengbu Medical College, Anhui Bengbu 233030, China
    2 Graduate School of Wannan Medical College, Anhui Wuhu 241002, China
    3 Department of Hernia and Obesity Surgery, the First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Anhui Hefei 230001, China

Received date: 2025-04-08

  Online published: 2026-06-23

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Abstract

Objective To systematically evaluate the therapeutic effect of laparoscopic Roux-en-Y gastric bypass (LRYGB) in patients with obesity comorbid with polycystic ovary syndrome (PCOS). Methods A systematic literature search was conducted across four databases (PubMed, Embase, Web of Science, and Scopus) for studies published up to January 1, 2025. Following screening against predefined eligibility criteria, a total of 6 studies comprising 128 patients were ultimately included. Results Following LRYGB, there was a significant reduction in the number of patients with menstrual irregularities (OR=0.07; 95%CI: 0.04~0.14; P<0.05). Additionally, significant improvements were observed in hirsutism (OR=0.14; 95%CI: 0.06~0.32; P<0.05), sex hormone-binding globulin (SHBG) (MD=23.24; 95%CI: 7.97~38.51; P<0.05), free androgen index (FAI) (MD=-3.89; 95%CI: -5.33~-2.45; P<0.05), total testosterone levels (MD=-25.55; 95%CI: -30.08~-21.01; P<0.05), and body mass index (BMI) (MD=-17.22; 95%CI: -19.32~-15.11; P<0.000 1). Conclusions LRYGB can serve as an effective therapeutic intervention to improve body weight and metabolic profiles in the population with obesity comorbid with PCOS.

Key words： Bariatric surgery; Laparoscopic Roux-en-Y gastric bypass (LRYGB); Polycystic ovary syndrome(PCOS); Obesity

Cite this article

WANG Shuhan , REN Zhen , WEI Xiaohan , LIU Hu , PAN Chen , WU Lisheng . Meta-analysis of the therapeutic effect of LRYGB in patients with obesity-related polycystic ovary syndrome[J]. Journal of Surgery Concepts & Practice, 2026 , 31(02) : 129 -136 . DOI: 10.16139/j.1007-9610.2026.02.06

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