组织工程与重建外科杂志 ›› 2025, Vol. 21 ›› Issue (5): 495-.

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机械力刺激对肌腱损伤修复的作用机制及应用研究

  

  • 出版日期:2025-10-13 发布日期:2025-10-30

Research on the mechanism and application of mechanical stimulation in tendon injury repair

  • Online:2025-10-13 Published:2025-10-30

摘要:

肌腱损伤是运动医学、关节骨科和整形外科领域中的常见问题,其修复过程复杂且易出现功能恢复不完全的情况,涉及多种细胞的参与和各种分子间的相互作用。由于肌腱缺乏血管供应,且自身的新陈代谢活动较少,其再生能力有限,因此肌腱损伤修复是医学领域目前面临的一项艰巨挑战。近年来,机械力刺激作为一种重要的物理干预手段,被广泛研究并应用于肌腱损伤的修复。在肌腱损伤修复过程中,机械力刺激可以通过调节细胞行为、影响炎症反应、改
善组织结构、促进血管生成等多种作用机制,促进肌腱的再生和功能恢复。现对机械力刺激作用于肌腱损伤修复的作
用机制及应用研究进行综述,为促进其在临床的应用提供依据。

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Abstract:

Tendon injury is a common problem in the fields of sports medicine, joint orthopedics and plastic surgery. Its
repair process is complex and prone to incomplete functional recovery, involving the participation of multiple cells and the interaction between various molecules. Due to the lack of vascular supply and less metabolic activity of tendons, their regenerative capacity is limited. Therefore, tendon injury repair is currently a formidable challenge in the medical field. In recent years, mechanical force stimulation, as an important physical intervention method, has been widely studied and applied in the repair of tendon injuries. During the process of tendon injury repair, mechanical force stimulation can promote the regeneration and functional recovery of tendons through multiple mechanisms of action, such as regulating cell behavior, influencing inflammatory responses, improving tissue structure, and promoting angiogenesis. In this paper, the mechanism and application research of mechanical stimulation in tendon injury repair were reviewed.

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