组织工程与重建外科杂志 ›› 2025, Vol. 21 ›› Issue (5): 514-.

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脂肪源性干细胞对乳房再造术后包膜挛缩的作用及相关研究进展

  

  • 出版日期:2025-10-13 发布日期:2025-10-30

Effect of ADSC on breast reconstruction capsular contracture and relevant research progress

  • Online:2025-10-13 Published:2025-10-30

摘要:

包膜挛缩是最为常见的植入物乳房再造并发症,会导致疼痛、不良的美容效果和再次手术。随着对脂肪组织中脂肪源性干细胞(Adipose-derived stem cells,ADSC)的认识和研究的不断深入,其多向分化潜能和旁分泌效应在乳房再造领域也受到关注。现对ADSC的特性及其在乳房再造术后包膜挛缩方面的基础和临床研究进展进行综述。

关键词:

Abstract:

Capsular contracture is the most common complication of implant- based breast reconstruction, resulting in pain, poor cosmetic results, and reoperations. With the deepening of the understanding and research of adipose-derived stem cells (ADSC) in adipose tissue, their multi-directional differentiation potential and paracrine effect have received certain attention in the field of breast reconstruction. In this paper, the characteristics of ADSC and their basic and clinical research progress in breast reconstruction capsular contracture were reviewed. In the future, studies on a larger scale are needed to confirm its therapeutic and preventive effects on implant-based breast reconstruction capsular contracture and its long-term safety.

Key words:

Postmastectomy radiation therapy