组织工程与重建外科杂志

组织工程与重建外科杂志 ›› 2022, Vol. 18 ›› Issue (3): 272-.

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自体脂肪及其衍生物移植在瘢痕治疗中的应用进展

  

  • 出版日期:2022-06-01 发布日期:2022-07-11

Progress in the use of autologous fat grafting and fat derivatives for scar treatment　

  • Online:2022-06-01 Published:2022-07-11

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摘要： 瘢痕是皮肤创伤后异常修复的结果，可造成功能障碍及外貌损毁，而现有瘢痕治疗方法的临床效果存在一定的局限性。近年来的多项研究发现，自体脂肪及其衍生物（纳米脂肪、基质血管成分胶状物）的移植可有效改善瘢痕外观、质地和局部症状。其机制可能与自体脂肪含有的多种细胞及其分泌物有关，这些组分可通过多种通路及机制干预瘢痕形成、改善瘢痕组织结构。本文就自体脂肪及其衍生物移植在瘢痕治疗中的应用进展，及其可能的作用机制进行归纳总结。

关键词: 瘢痕, 　脂肪移植, 　衍生物, 　机制

Abstract: Scars result from abnormal regeneration after skin injuries, causing disfigurement and functional impairment. However, current treatments for scars are unsatisfactory to a certain extent. In recent years, numerous researches indicate that autologous fat grafting and the application of fat derivatives (nanofat, SVF-gel) could effectively improve the appearance, texture, and local symptoms of scars. The curative effect of the adipose tissue might be attributed to the wide range of cells it comprises and the secretome thereof, which could interfere in scar formation and reconstruct the scar tissue through a variety of pathways and mechanisms. In this paper, the progress in the application of autologous fat grafting and fat derivatives for scar treatment and the possible mechanisms therein were reviewed.

Key words: Scars, 　Fat grafting, 　Derivative, 　Mechanism