组织工程与重建外科杂志 ›› 2022, Vol. 18 ›› Issue (4): 345-.

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生物活性玻璃在软组织修复中的应用

  

  • 出版日期:2022-08-01 发布日期:2022-09-07

Application of bioactive glasses on soft tissue repair 

  • Online:2022-08-01 Published:2022-09-07

摘要: 生物活性玻璃(Bioactive glasses,BGs)已经在再生医学和组织工程领域有了广泛应用,其与体液接触可产生碳酸羟基磷灰石,从而与骨组织紧密结合,所以常用于骨缺损或牙齿的替代、再生及修复。随着技术与材料的逐渐发展,越来越多的证据证明了BGs在软组织修复中的发展潜力。BGs具备一定的抗菌作用,这种特性在组织修复中的优势明显,通过改变其组分,或与不同材料(如功能性离子、聚合物、生物因子等)结合,能更快速有效地促进伤口愈合。本文回顾了BGs的发展进程,并通过伤口修复机制探讨BGs加速伤口修复的可能机制,最后对BGs在伤口修复中的研究发展趋势进行解读。

关键词: 生物活性玻璃,  伤口愈合,  组织工程

Abstract: Bioactive glasses (BGs) have been widely used in regenerative medicine and tissue engineering. It can produce hydroxy carbonate apatite (HCA) when contact with body fluids, and thus closely bind with bone tissue, so it is often used in the replacement, regeneration and repair of bone defects or teeth. With the development of technology and bioactive materials, more and more evidence has proved the potential of BGs in soft tissue repair. BGs itself has antibacterial effect, which has obvious advantages in soft tissue repair. By changing its composition or combining with different materials such as functional ions, polymers and biological factors, BGs can promote wound healing more quickly and effectively. In this paper, the development of BGs was reviewed, and the possible mechanism of BGs accelerating wound repair was discussed by comparing with the mechanism of wound repair. Finally, the research trend of BGs in wound repair was interpreted.

Key words: Bioactive glasses,  Wound healing,  Tissue engineeringt