组织工程与重建外科杂志 ›› 2024, Vol. 20 ›› Issue (3): 382-.

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紫外线辐射致皮肤老化机制的研究进展

  

  • 出版日期:2024-06-01 发布日期:2024-07-05

Research progress on the mechanism of skin aging caused by ultraviolet radiation

  • Online:2024-06-01 Published:2024-07-05

摘要:

长期日光暴露下的皮肤会出现功能受损甚至遗传物质改变,表现为水分丢失、弹性缺失、皱纹生长、黑色素沉
着及干燥等老化特征。引起皮肤光老化的方式繁多且机制复杂,日光中的紫外线对皮肤老化的影响尤其明显,能作用
于皮肤的紫外线分为UVA和UVB两种,主要通过氧化应激、损伤遗传物质、改变表皮微生物群落、破坏细胞器功能与结
构、重塑细胞外基质(ECM)等5种机制作用于皮肤而导致光老化。本文对这5种机制进行综述,以期为紫外线辐射所致
皮肤老化的治疗提供参考。

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Abstract:

Skin exposed to sunlight for a long period of time will have impaired function and even genetic material
alteration, which is manifested by aging characteristics such as water loss, elasticity loss, wrinkle growth, melanin
deposition and dryness. There are many ways to cause skin photoaging and the mechanism is complex, the ultraviolet light in
sunlight has a particularly obvious effect on skin aging, the ultraviolet light that can act on the skin is divided into two kinds:
UVA and UVB. They mainly act on the skin through five mechanisms that lead to photoaging: oxidative stress, damaging
genetic material, changing the epidermal microbial community, destroying the function and structure of organelles, and
reshaping the extracellular matrix (ECM).In this paper, these five mechanisms were reviewed, and research directions and
prospects in this field were proposed.

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