组织工程与重建外科杂志 ›› 2025, Vol. 21 ›› Issue (5): 502-.

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生物活性玻璃对糖尿病皮肤创面修复的研究进展

  

  • 出版日期:2025-10-13 发布日期:2025-10-30

Research progress of bioactive glass in diabetic skin wound healing

  • Online:2025-10-13 Published:2025-10-30

摘要:

糖尿病难愈性皮肤创面是糖尿病常见的严重并发症之一,其发病机制复杂,主要与持续高糖状态、微循环障
碍、感染及炎症反应失调等多因素密切相关。这类创面具有迁延不愈的临床特点,不仅显著影响患者生活质量,更是当
前糖尿病治疗领域面临的重大挑战。近年来,生物活性玻璃以其独特的生物相容性、促血管生成特性和抗菌性在软组
织修复的应用中得到越来越多的关注。现就不同形态生物活性玻璃在糖尿病创面治疗中的最新研究进展进行综述,以
期为优化糖尿病创面的愈合策略提供新的思路。

关键词:

Abstract:

Diabetic refractory cutaneous wounds, as one of the most severe complications of diabetes mellitus, present
complex pathogenesis primarily attributed to persistent hyperglycemia, micro-circulatory dysfunction, infection, and dysregulated inflammatory responses. Characterized by prolonged non-healing properties, these wounds not only significantly impair patients’ quality of life but also pose a major therapeutic challenge in current diabetes management. In recent years, bioactive glass has garnered increasing attention in soft tissue repair applications due to its unique bio-compatibility, proangiogenic properties, and antimicrobial efficacy. In this paper, recent advances in the application of bioactive glasses with different morphologies for diabetic wound treatment were reviewed, aiming to provide novel insights for optimizing therapeutic strategies for diabetic wound healing.

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