各种物理性、机械性、化学性和病原微生物性的刺激均可能导致外分泌腺腺体的损伤,从而使其分泌功能下降。外分泌腺腺体损伤后药物治疗的效果有限,器官移植风险大且供体不足。而间充质干细胞(Mesenchymal stem cells,MSCs)因其强大的增殖能力、多向分化能力及旁分泌/自分泌作用,为修复各种外分泌腺损伤提供了一种新思路。本文就MSCs的旁分泌作用在外分泌腺组织工程中的应用及研究进展进行综述。

A variety of physical, mechanical, chemical and pathogenic microbial stimuli may cause damage to the exocrine glands, resulting in decreased secretion. The effect of drug therapy is limited, the risk of organ transplantation is high with limited donor. The mesenchymal stem cells provide a new idea for the repair of various exocrine glandular damages because of its strong proliferation ability, multi-differentiation ability and paracrine/autocrine effects. In this paper, the application and research progress of paracrine effects of mesenchymal stem cells in exocrine tissue engineering were reviewed.