目的 探索平阳霉素对小儿口腔颌面部血管瘤及血管畸形的治疗效果。方法 2015年1月至2018年1月,76例口腔颌面部血管瘤及血管畸形患儿根据单盲原则分为对照组(n=38)与治疗组(n=38)。对照组接受地塞米松治疗,治疗组(n=38)接受平阳霉素治疗。对比两组患者的治疗效果和不良反应情况。结果 治疗组有效率显著高于对照组(P<0.05)。治疗组与对照组治疗前瘤体面积差异不显著(P>0.05);治疗后两组患儿瘤体面积均明显减少(P<0.05),且治疗组瘤体面积显著小于对照组(P<0.05)。治疗组不良反应发生率显著低于对照组(P<0.05)。结论 平阳霉素治疗小儿口腔颌面部血管瘤及血管畸形,效果理想,安全性较高,值得临床推广应用。

Objective To explore the effect of Pingyang mycin on hemangioma and vascular malformation in oral and maxillofacial region of children.Methods From January 2015 to January 2018,76 cases with oral and maxillofacial hemangioma and vascular malformation in children were randomly selected.According to the principle of single blindness,76 cases were divided into control group and treatment group.Patients in control group(n=38)were treated with dexamethasone,while patients in treatment group(n=38)were treated with pingyang mycin.The therapeutic effects and adverse reactions of the two groups were observed and compared.Results The effective rate of treatment group was significantly higher than that of control group(P<0.05).There was no significant difference in pre-treatment tumor area between the treatment group and the control group(P>0.05);After treatment,the tumor area of the two groups were both significantly reduced(P<0.05),and the tumor area of the treated group was significantly smaller than that of the control group(P<0.05).The incidence of adverse reactions in treatment group was significantly lower than that in control group(P<0.05).Conclusion Pingyang mycin is effective and safe in treating oral and maxillofacial hemangioma and vascular malformation in children,and is worthy of clinical promotion.