随着透明质酸在整形美容外科的应用不断增加,发生严重并发症的例数也相应增多.透明质酸酶作为透明质酸专一性水解酶,在治疗透明质酸注射术后并发症方面有着显著疗效.现将透明质酸酶的基本性质,临床应用,尤其是在并发症治疗方面的应用,以及所涉及的不良反应进行综述.

As injection of hyaluronic acid has become increasingly popular, more complications, especially intravascular embolisms, have been reported in the recent years. Hyaluronidase, as specific hydrolase, have been proposed to treat such horrific adverse events. To further understand the nature and application of this enzyme, the biochemistries, clinical applications, especially in the treatment of hyaluronic acid induced complications, and adverse reactions were reviewed.