研究证实小鼠皮肤树突状表皮γδT细胞(Dendritic epidermalγδT cells,DETCs)表达的γδTCR,由Vγ3Jγ1-Cγ1和Vδ1Dδ2Jδ2-Cδ链组成,特异性表达于成年小鼠皮肤中。DETCs活化后分泌多种细胞因子、生长因子、趋化因子等,这些因子与组织修复,以及细胞存活、增殖、迁移和募集有关,在维持上皮组织完整性和上皮组织修复中发挥关键作用。本文就DETCs在维持上皮组织的完整和组织修复过程中的作用进行综述。

The research showed that the dendritic epidermal γδ T cells (DETCs) found in murine skin expressed aγδTCR composed of Vγ3Jγ1-Cγ1and Vδ1Dδ2Jδ2-Cδ chains which specifically expressed in murine skin. Activated DETCs produce several cytokines, growth factors and chemokines. All these factors were related to tissue repair, cell survival, proliferation, migration, recruitment, and play a key role in maintaining the epithelium integrity and repairing the epithelial tissue. In this paper, the functions of DETCs in maintaining the epithelium integrity and would repair were reviewed.