小口径血管是组织工程血管领域的重要部分,临床实用性强。小口径血管支架的合成是构建小口径人工血管的基础,而电纺技术作为一种新型的组织工程材料制备技术,可利用高压静电场产生微米级甚至是纳米级的纤维,再经过一系列加工处理,形成类似细胞外基质的结构,刺激细胞的黏附和增殖。本文对小口径电纺组织工程血管支架的相关材料、制备工艺、表面修饰和评价进行综述。

The preparation of small-diameter blood vessels is an important part in the field of tissue engineering blood vessels, which has strong practicability in clinic. Synthesis of small-diameter vascular grafts is the basic of the construction of small-diameter artificial blood vessels. Electrospinning is a new technology of tissue engineering preparations. It can use a high voltage electrostatic field to produce micron grade even the nanoscale fibers. And through a series of processing, making the grafts simulate to extracellular matrix, cell adhesion and proliferation can be stimulated. In this paper, the materials, preparation technics, surficial decorations and evaluation system of the small-diameter tissue engineering blood vessel grafts were all reviewed.