间充质干细胞作为种子细胞在组织工程和再生医学领域有极大的应用前景,尤其是在骨组织工程中的应用受到了广泛关注。间充质干细胞的成骨分化机制复杂,受到多方面因素的影响,不同种类的mi RNA可分别参与抑制或促进间充质干细胞的成骨分化,在其分化过程中具有核心作用。本文对不同作用的mi RNA进行归类和总结,期待为未来的研究提供思路。

Mesenchymal stem cells have great application prospects in tissue engineering and regenerative medicine as seed cells, especially have evoked the extensive attention in the application of bone tissue engineering. Mechanisms of osteogenic differentiation of mesenchymal stem cells are complicated. It is affected by various factors. Different kinds of miRNA can inhibit or promote the osteogenic differentiation of mesenchymal stem cells respectively, it plays a key role in the differentiation process. In this paper, miRNA in different roles was classified and summarized, expecting to provide ideas for future research.