超顺磁性氧化铁纳米颗粒(SPIONs)是一种在细胞标记、药物靶向投递、肿瘤热治疗等领域,都有着广泛应用前景的纳米材料。再生医学研究中,干细胞的研究和应用广受关注,SPIONs的出现为干细胞的标记和示踪提供了新的途径。SPIONs具有超顺磁性、低毒性、良好生物相容性,以及在外加磁场下定向移动等特点。SPIONs在MRI成像上表现为信号减弱区域,经过表面修饰后可有效、安全地标记干细胞,但同时也存在细胞毒性不明确和MRI成像限制性等问题。本文就超顺磁性氧化铁纳米颗粒标记干细胞的研究进展进行综述。

Superparamagnetic iron oxide nanoparticles （SPIONs） are a kind of nano materials which have broad application prospects in the field of labeling cells, targeted drug delivery and heat treatment of tumor. Especially in regenerative medicine, more and more research and application of stem cells have been founded. SPIONs have provided a new method to label and track cells. The characteristics of SPIONs are superparamagnetic, low toxicity, good biocompatibility and directional movement in the magnetic field. SPIONs present low signal area in magnetic resonance imaging （MRI） and they can label cells safely and effectively with appropriate coatings. But the uncertainty of cytotoxicity and the limitation of MRI are still unsolved. In this paper, the research progress of SPIONs in labeling cells were reviewed.