目的 探讨应用博来霉素(BLM)注射硬化治疗微囊型淋巴管畸形(LMs)的有效性。方法 2009年1月至2013年12月,共32例皮肤微囊型LMs患者接受治疗。应用B超确定病变范围和层次,以BLM进行皮肤病损组织内注射硬化治疗。治疗间隔4~6周。结果 每例患者平均治疗3.5次,30例治愈,2例显效。随访1~4年,B超证实无复发微囊腔出现,无药物副作用发生。结论 应用BLM硬化注射治疗皮肤微囊型淋巴管畸形安全有效,能基本治愈。

Objective To explore the effectiveness of local bleomycin injection in the treatment of microcystic lymphatic malformations （LMs）. Methods From January 2009 to December 2013, 32 patients with microcystic LMs were treated by bleomycin injection and followed prospectively. Ultrasound examination were used to confirm the diagnosis and determine the scope and level of the cyst before bleomyein injection. Each patient received bleomyein injection at an interval of 4 to 6 weeks. Results The mean injection times was 3.5 times. Thirty cases were cured and 2 cases were partially cured. All the patients were followed up for 1-4 years. Ultrasound follow-up demonstrated no recurrence of microcystic LMs. And no drug side-effects were observed. Conclusion Local application of bleomyein in patients with microcystic LMs is a safe and effective method. Totally healing can be achieved in the majority of cases.