羊水来源干细胞的属性介于胚胎干细胞与成体干细胞之间,保留有间充质干细胞类似的未分化属性,因无致瘤性、不促发同种异体免疫反应而受到关注。目前,有关其细胞来源及特性、骨向诱导分化及培养,以及在组织工程的应用等方面的研究日益增多。研究认为,羊水来源干细胞的骨向分化有望成为骨缺损修复的新的骨组织来源。本文对羊水来源干细胞骨向分化的研究进展进行综述。

Amniotic fluid-derived stem cell is in a medium state between embryonic stem cell and adult stem cell, maintaining undifferentiated property. As not tumorigenic, its stern cell potentiality and immunomodulator properties make it an attractive candidate for cell therapy approaches. Till now, documented reports on the cell origin, characteristics, osteogenic differentiation, cuhivation and its tissue engineering application have been raised, regarding the cell lineage as a reasonable source for bone-defect reconstruction. Hereby, a review paper is made to conclude research progress on osteogenic differentiation of amniotic fluid-derived stem cell.